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The major biochemical abnormality is conjugated hyperbilirubinaemia.<\/jats:p>\n                  <jats:p>The clinical setting suggests that hepatic ischaemia and hepatotoxic actions of inflammatory mediators are the major aetiological factors. Massive blood transfusion, effects of nutritional support and drug toxicity may contribute.<\/jats:p>\n                  <jats:p>Both the presence and degree of jaundice are associated with increased mortality in several nonhepatic diseases. It is proposed that Kupffer cell phagocytic depression associated with liver dysfunction permits systemic spread of endotoxin and inflammatory mediators and thus predisposes to multiple organ failure. Immunosuppression, metabolic abnormalities, impaired drug oxidation and myocardial depression may contribute to the poor prognosis.<\/jats:p>\n                  <jats:p>There is no specific treatment, but prompt resuscitation, definitive treatment of sepsis and meticulous supportive care will likely reduce the incidence and severity.<\/jats:p>","DOI":"10.1177\/0310057x9101900203","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T17:54:33Z","timestamp":1547488473000},"page":"165-181","source":"Crossref","is-referenced-by-count":83,"title":["Liver Dysfunction in Critical Illness"],"prefix":"10.1177","volume":"19","author":[{"given":"F.","family":"Hawker","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Royal Prince Alfred Hospital, Sydney, New South 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