{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:16:56Z","timestamp":1792192616935,"version":"4.4.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:p>In a retrospective survey of all adults admitted to the Intensive Care Unit with acute theophylline poisoning over the last five years, we identified 38 patients (6.8% of all admissions for poisoning), two of whom died. Thirty-five (92%) had taken a sustained-release preparation. Eight patients had grand mal seizures and six developed arrhythmias (ventricular fibrillation, 3; atrial fibrillation, 2; supraventricular tachycardia, 1). Severe vomiting was present in 34 (89%) and proved to be a serious obstacle to the administration of enteral charcoal. The vomiting was controlled by intravenous metoclopramide in seventeen patients (50%), but the remaining seventeen required mechanical ventilation with sedation and muscle relaxation for the effective delivery of nasogastric charcoal. Importantly, in nine (24%), the serum theophylline concentration continued to rise despite enteral charcoal. Charcoal haemoperfusion was used in seven (18%). We present an algorithm for the management of severe, acute theophylline poisoning.<\/jats:p>","DOI":"10.1177\/0310057x9202000111","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T03:51:49Z","timestamp":1547610709000},"page":"56-62","source":"Crossref","is-referenced-by-count":27,"title":["Management of Theophylline Overdose Patients in the Intensive Care Unit"],"prefix":"10.1177","volume":"20","author":[{"given":"A.","family":"Henderson","sequence":"first","affiliation":[{"name":"Intensive Care Unit and University of Queensland Department of Medicine, Princess Alexandra Hospital, Brisbane, Queensland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Wright","sequence":"additional","affiliation":[{"name":"Intensive Care Unit and University of Queensland Department of Medicine, Princess Alexandra Hospital, Brisbane, Queensland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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