{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:50:58Z","timestamp":1777377058597,"version":"3.51.4"},"reference-count":69,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1994,8,1]],"date-time":"1994-08-01T00:00:00Z","timestamp":775699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:p>\n                    With the widespread availability of capnography, many anaesthetists have swung away from formally verifying hypocapnia by intraoperative arterial blood gas analysis and, instead, have come to rely upon capnography as an acceptable and constant predictor of arterial CO\n                    <jats:sub>2<\/jats:sub>\n                    tension (P\n                    <jats:sub>a<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    ) during neurosurgery. However, the nature of the arterial-endtidal CO\n                    <jats:sub>2<\/jats:sub>\n                    gradient is complex, and is frequently unexpectedly large, or even negative. The importance of close intraoperative CO\n                    <jats:sub>2<\/jats:sub>\n                    control during neurosurgery\u2014more specifically, routine hyperventilation, and our reliance upon capnography to guide intraoperative management\u2014is reappraised. There is a growing appreciation of the adverse effects of hyperventilation and hypocarbia, especially upon abnormal or ischaemic brain, and it is clear that capnography alone cannot be used to confidently predict the true P\n                    <jats:sub>a<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    during neuroanaesthesia.\n                  <\/jats:p>","DOI":"10.1177\/0310057x9402200419","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T17:53:03Z","timestamp":1548179583000},"page":"435-441","source":"Crossref","is-referenced-by-count":18,"title":["Control of Carbon Dioxide Levels during Neuroanaesthesia: Current Practice and an Appraisal of our Reliance upon Capnography"],"prefix":"10.1177","volume":"22","author":[{"given":"P.","family":"Isert","sequence":"first","affiliation":[{"name":"Prince of Wales Hospital, Sydney, 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