{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:01:07Z","timestamp":1792422067344,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1995,10,1]],"date-time":"1995-10-01T00:00:00Z","timestamp":812505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:p>The efficacy of epidural corticosteroids in the treatment of sciatica was investigated by meta-analysis of all randomized controlled trials. Eleven suitable trials of good quality were identified involving a total of 907 patients.<\/jats:p>\n                  <jats:p>The use of epidural (caudal or lumbar) steroid in the short-term (up to 60 days) increased the odds ratio (OR) of pain relief (&gt;75% improvement) to 2.61 (95% CI 1.90\u20133.77) when compared with placebo. Despite some variations in trial characteristics there was little evidence of significant heterogeneity (P=0.07). When the trials were analysed for near or total relief of pain in the short-term the OR is 2.79 (95% CI 1.92\u20134.06), for heterogeneity (P=0.07). For longterm relief of pain (up to 12 months) the OR is 1.87 (95% CI 1.31\u20132.68).<\/jats:p>\n                  <jats:p>Efficacy is independent of the route of injection; for caudal epidural steroid the OR is 3.80 (95% CI 1.36\u201310.6) and for the lumbar epidural steroid 2.43 (95% CI 1.77\u20133.74).<\/jats:p>\n                  <jats:p>Adverse events included dural tap (2.5%), transient headache (2.3%) and a transient increase in pain (1.9%). There were no reported longterm adverse events.<\/jats:p>\n                  <jats:p>In conclusion we present quantitative evidence from meta-analysis of pooled data from randomized trials that epidural administration of corticosteroids is effective in the management of lumbosacral radicular pain.<\/jats:p>","DOI":"10.1177\/0310057x9502300506","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T18:12:33Z","timestamp":1548180753000},"page":"564-569","source":"Crossref","is-referenced-by-count":168,"title":["A Meta-Analysis on the Efficacy of Epidural Corticosteroids in the Treatment of Sciatica"],"prefix":"10.1177","volume":"23","author":[{"given":"R. W.","family":"Watts","sequence":"first","affiliation":[{"name":"\u201cThe Investigator\u201d Clinic, Port Lincoln, South Australia and the Department of General Practice, The Flinders University of South Australia, Bedford Park, South Australia"},{"name":"Department of General Practice, The Flinders University of South Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Silagy","sequence":"additional","affiliation":[{"name":"\u201cThe Investigator\u201d Clinic, Port Lincoln, South Australia and the Department of General Practice, The Flinders University of South Australia, Bedford Park, South Australia"},{"name":"The Flinders University of South Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1995,10,1]]},"reference":[{"key":"bibr1-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(85)90146-0"},{"key":"bibr2-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1985.tb123102.x"},{"key":"bibr3-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.3109\/17453677708994810"},{"key":"bibr4-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5867.635"},{"key":"bibr5-0310057X9502300506","doi-asserted-by":"crossref","unstructured":"BenzonHT. Epidural steroid injections for low back pain and lumbo sacral radiculopathy. Pain 1986; 277\u2013295.","DOI":"10.1016\/0304-3959(86)90115-6"},{"key":"bibr6-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/11.1.40"},{"key":"bibr7-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/17.3.181"},{"key":"bibr8-0310057X9502300506","first-page":"927","volume":"1","author":"Breivik H","year":"1976","journal-title":"Advance Pain Res Ther"},{"key":"bibr9-0310057X9502300506","unstructured":"BodukN, BrazenorG, ChristophidisN, et al. Epidural use of steroids in the management of back pain and sciatica of spinal origin. National Health and Medical Research Council (NHMRC) 1994."},{"key":"bibr10-0310057X9502300506","unstructured":"ChalmersI, EnkinM, KeirseMJNC, eds. Effective care in pregnancy and childbirth. Oxford, Oxford University Press, 1985."},{"key":"bibr11-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(85)80003-7"},{"key":"bibr12-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.2307\/3001666"},{"key":"bibr13-0310057X9502300506","first-page":"511","volume":"21","author":"Czarski Z.","year":"1965","journal-title":"Przeglad Lekarski"},{"key":"bibr14-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1970.tb00218.x"},{"key":"bibr15-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/23.1.35"},{"key":"bibr16-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198567010-00009"},{"key":"bibr17-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/26.6.416"},{"key":"bibr18-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/27.4.295"},{"key":"bibr19-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199105000-00015"},{"key":"bibr20-0310057X9502300506","unstructured":"PopiolekA, DomanikA, MazurkiewiczG. Leczenie sterydowymi ostrzknieciami nadopow owymi chorychz prewlekla rwa kulszowa w przebiegu dyskopatti. Neur Neurochir Pol 1991; T 25 NR5 640\u2013646."},{"key":"bibr21-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1007\/BF02076016"},{"key":"bibr22-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6982.752"},{"key":"bibr23-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6982.751"},{"key":"bibr24-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5218.20"},{"key":"bibr25-0310057X9502300506","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199210000-00013"},{"key":"bibr26-0310057X9502300506","unstructured":"GurscheB. Lumbar epidural analgesia in obstetrics; taps and patches. In: Epidural and spinal blockade in obstetrics. ReynoldsF., ed. Bailliere Tindall 1990; 95\u2013106."}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X9502300506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X9502300506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:07:24Z","timestamp":1777367244000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X9502300506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.1177\/0310057X9502300506"],"URL":"https:\/\/doi.org\/10.1177\/0310057x9502300506","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}