{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:57:34Z","timestamp":1777377454183,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p>Two case reports are presented where inhaled aerosolized prostacyclin (IAP) was used to good effect as a selective pulmonary vasodilator. It was used in the treatment of a patient with severe hypoxaemia secondary to amniotic fluid embolism and for hypoxaemia secondary to the acute respiratory distress syndrome (ARDS) in a patient with acute on chronic liver failure and intra-abdominal sepsis. An apparent dose-response curve is demonstrated in the second case. A dose of IAP of 30\u201340 ng\/kg\/min produced an effect on oxygenation in the patient with liver failure equal to that seen at the maximal dose of (50 ng\/kg\/min). Reduction in dose below 30 ng\/kg\/min resulted in a deterioration in oxygenation towards baseline\/pre-treatment levels. Inhaled aerosolized prostacyclin is a potent pulmonary vasodilator with little or no systemic hypotensive effect. It is simple to administer and would appear to be a viable alternative to inhaled nitric oxide.<\/jats:p>","DOI":"10.1177\/0310057x9602400115","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T13:34:48Z","timestamp":1547472888000},"page":"87-90","source":"Crossref","is-referenced-by-count":44,"title":["Inhaled Aerosolized Prostacyclin as a Selective Pulmonary Vasodilator for the Treatment of Severe Hypoxaemia"],"prefix":"10.1177","volume":"24","author":[{"given":"P. V.","family":"Van Heerden","sequence":"first","affiliation":[{"name":"Department of Intensive Care, Sir Charles Gairdner Hospital, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A. R.","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Sir Charles Gairdner Hospital, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Hee","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Sir Charles Gairdner Hospital, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Corkeron","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Sir Charles Gairdner Hospital, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Sir Charles Gairdner Hospital, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,2,1]]},"reference":[{"key":"bibr1-0310057X9602400115","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.3.773"},{"issue":"2","key":"bibr2-0310057X9602400115","first-page":"213","volume":"103","author":"Devitt HH","year":"1988","journal-title":"Surgery"},{"key":"bibr3-0310057X9602400115","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92004-D"},{"key":"bibr4-0310057X9602400115","doi-asserted-by":"publisher","DOI":"10.1159\/000129297"},{"key":"bibr5-0310057X9602400115","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/138.3.720"},{"key":"bibr6-0310057X9602400115","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-0770(05)80322-2"},{"key":"bibr7-0310057X9602400115","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92405-8"},{"key":"bibr8-0310057X9602400115","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199406000-00009"},{"key":"bibr9-0310057X9602400115","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.5.8173780"},{"key":"bibr10-0310057X9602400115","first-page":"724","volume":"151","author":"Walmrath D","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"bibr11-0310057X9602400115","doi-asserted-by":"crossref","unstructured":"WebbSAR, StottS, van HeerdenPV. The use of inhaled prostacyclin in the treatment of pulmonary hypertension secondary to pulmonary embolism. Intens Care Med 1996 (in press).","DOI":"10.1007\/BF01700458"},{"key":"bibr12-0310057X9602400115","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408043310519"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X9602400115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X9602400115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:07:39Z","timestamp":1777367259000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X9602400115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["10.1177\/0310057X9602400115"],"URL":"https:\/\/doi.org\/10.1177\/0310057x9602400115","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}