{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:32:22Z","timestamp":1791329542983,"version":"4.3.1"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1997,6,1]],"date-time":"1997-06-01T00:00:00Z","timestamp":865123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:p>\n                    The longterm effects of ketamine on haemodynamic parameters and exogenous catecholamine requirements were studied in twenty-five critically ill patients with catecholamine-dependent heart failure. Following sedation with midazolam (0.15\u00b10.07 mg.kg\n                    <jats:sup>\u20131<\/jats:sup>\n                    .h\n                    <jats:sup>\u20131<\/jats:sup>\n                    ) and sufentanil (0.88\u00b10.33 \u03bcg.kg\n                    <jats:sup>\u20131<\/jats:sup>\n                    .h\n                    <jats:sup>\u20131<\/jats:sup>\n                    ), patients with impaired left ventricular function (left ventricular ejection fraction area 30\u00b17%) were randomly assigned to receive ketamine (2.5\u00b10.9 mg.kg\n                    <jats:sup>\u20131<\/jats:sup>\n                    .h\n                    <jats:sup>\u20131<\/jats:sup>\n                    ) and midazolam (Group A) or remained on sufentanil\/midazolam (Group B). Haemodynamic measurements were performed throughout the first 24 hours after randomization. In group A cardiac index decreased by 21% (P=0.01), mean arterial pressure increased by 13% (P=0.01), mean pulmonary artery pressure by 14% (P=0.04), pulmonary capillary wedge pressure by 20% (P=0.03), and systemic vascular resistance index by 38% (P&lt;0.001). No significant cardiovascular effects were observed in Group B. Neither group had significant changes of exogenous catecholamine requirement.\n                  <\/jats:p>\n                  <jats:p>In conclusion, ketamine exhibits potential negative cardiovascular effects in patients with catecholamine-dependent heart failure. Therefore, ketamine should not be considered a first line drug for longterm sedation of patients with impaired left ventricular function.<\/jats:p>","DOI":"10.1177\/0310057x9702500308","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T03:54:50Z","timestamp":1547610890000},"page":"255-259","source":"Crossref","is-referenced-by-count":73,"title":["Adverse Cardiovascular Effects of Ketamine Infusion in Patients with Catecholamine-Dependent Heart Failure"],"prefix":"10.1177","volume":"25","author":[{"given":"G.","family":"Christ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mundigler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Merhaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zehetgruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kratochwill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Siostrzonek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1997,6,1]]},"reference":[{"key":"bibr1-0310057X9702500308","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198202000-00007"},{"key":"bibr2-0310057X9702500308","first-page":"367","volume-title":"Status of Ketamine in Anesthesiology.","author":"Davies I.","year":"1990"},{"key":"bibr3-0310057X9702500308","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/50.4.375"},{"key":"bibr4-0310057X9702500308","first-page":"268","volume":"37","author":"Adams H.A.","year":"1988","journal-title":"Anaesthesist"},{"key":"bibr5-0310057X9702500308","first-page":"238","volume":"40","author":"Adams H.A.","year":"1991","journal-title":"Anaesthesist"},{"key":"bibr6-0310057X9702500308","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5920.656"},{"key":"bibr7-0310057X9702500308","first-page":"410","volume":"194","author":"Schwartz D.A.","year":"1975","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr8-0310057X9702500308","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-6296(89)97171-8"},{"key":"bibr9-0310057X9702500308","doi-asserted-by":"publisher","DOI":"10.1007\/BF03008186"},{"key":"bibr10-0310057X9702500308","doi-asserted-by":"publisher","DOI":"10.1007\/BF02239565"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X9702500308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X9702500308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:03:15Z","timestamp":1777366995000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X9702500308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,6]]}},"alternative-id":["10.1177\/0310057X9702500308"],"URL":"https:\/\/doi.org\/10.1177\/0310057x9702500308","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,6]]}}}