{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:38:51Z","timestamp":1777376331577,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1999,8,1]],"date-time":"1999-08-01T00:00:00Z","timestamp":933465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p>\n                    This study examined some pharmacodynamic characteristics of two admixtures of propofol and thiopentone. Ninety unpremedicated ASA 1 or 2 patients were group-randomized to receive, in a double-blinded manner, one of the following mixtures for induction of anaesthesia: Group P\n                    <jats:sub>50<\/jats:sub>\n                    : propofol 1% 10ml\/thiopentone 2.5% 10 ml; Group P\n                    <jats:sub>75<\/jats:sub>\n                    : propofol 1% 15 ml\/thiopentone 2.5% 5 ml; Group P\n                    <jats:sub>100<\/jats:sub>\n                    : propofol 1% 20 ml\/lignocaine 1% 4 ml. An additional 30 randomized but unblinded patients from the same patient cohort received thiopentone 2.5% to provide predictive dose data for groups P\n                    <jats:sub>50<\/jats:sub>\n                    and P\n                    <jats:sub>75<\/jats:sub>\n                    . Haemodynamic data were collected pre- and post-induction.\n                  <\/jats:p>\n                  <jats:p>\n                    The required induction dose of both mixtures of propofol and thiopentone found an additive rather than a synergistic interaction with no significant difference between predicted and observed dose. Thiopentone resulted in significantly more rapid induction of anaesthesia than propofol\/lignocaine or propofol\/thiopentone. The addition of thiopentone to propofol was found to be as efficacious as the mixing of lignocaine with propofol in reducing pain on injection. The fall in systolic blood pressure was significantly less in group P\n                    <jats:sub>50<\/jats:sub>\n                    compared with groups P\n                    <jats:sub>75<\/jats:sub>\n                    or P\n                    <jats:sub>100<\/jats:sub>\n                    .\n                  <\/jats:p>\n                  <jats:p>Admixture of thiopentone with propofol results in an additive hypnotic effect, a reduction in pain of injection (comparable with addition of lignocaine) and a reduced hypotensive response compared to propofol injection alone during induction.<\/jats:p>","DOI":"10.1177\/0310057x9902700403","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T03:56:08Z","timestamp":1547610968000},"page":"346-356","source":"Crossref","is-referenced-by-count":12,"title":["Propofol-Thiopentone Admixture\u2014Hypnotic Dose, Pain on Injection and Effect on Blood Pressure"],"prefix":"10.1177","volume":"27","author":[{"given":"D.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, The University of Queensland, Royal Brisbane Hospital, Brisbane, Queensland"},{"name":"Division of Anaesthesiology and Intensive Care, The University of Queensland, Royal Brisbane Hospital."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Prankerd","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, The University of Queensland, Royal Brisbane Hospital, Brisbane, Queensland"},{"name":"School of Pharmacy, University of Queensland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, The University of Queensland, Royal Brisbane Hospital, Brisbane, Queensland"},{"name":"Division of Anaesthesiology and Intensive Care, Royal Brisbane Hospital."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Chilvers","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, The University of Queensland, Royal Brisbane Hospital, Brisbane, Queensland"},{"name":"Department of Anaesthetics, Royal Women's Hospital, Brisbane."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bignell","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, The University of Queensland, Royal Brisbane Hospital, Brisbane, Queensland"},{"name":"Department of Anaesthetics, Royal Women's Hospital, Brisbane."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Short","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, The University of Queensland, Royal Brisbane Hospital, Brisbane, Queensland"},{"name":"Pharmacology and Clinical Pharmacology, Faculty of Medicine and Health Science, The University of Auckland, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,8,1]]},"reference":[{"key":"bibr1-0310057X9902700403","first-page":"1","volume":"121","author":"White P.F.","year":"1993","journal-title":"Annual Refresher Course Lectures"},{"key":"bibr2-0310057X9902700403","first-page":"896","volume":"80","author":"Chung F.","year":"1995","journal-title":"Anesth Analg"},{"issue":"3","key":"bibr3-0310057X9902700403","first-page":"80","volume":"61","author":"Uppington J.","year":"1985","journal-title":"Postgrad Med"},{"key":"bibr4-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1990.tb14328.x"},{"key":"bibr5-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1994.tb04462.x"},{"key":"bibr6-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/65.3.346"},{"key":"bibr7-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/53.21.2606"},{"key":"bibr8-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/67.1.4"},{"key":"bibr9-0310057X9902700403","volume-title":"Macclesfield","author":"Diprivan product information.","year":"1993"},{"key":"bibr10-0310057X9902700403","volume-title":"Pentothal product information.","year":"1993"},{"key":"bibr11-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(97)70268-X"},{"key":"bibr12-0310057X9902700403","unstructured":"PalmerT.E.A., CumpstonP.H.V., JonesR.D.M. MADAM: Multichannel anaesthetic data acquisition machine. ANZCA ASM, Townsville; May 1995; 61."},{"key":"bibr13-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600720824"},{"key":"bibr14-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(87)80394-8"},{"key":"bibr15-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1191\/096813098672023998"},{"key":"bibr16-0310057X9902700403","first-page":"1131","volume-title":"Principles and Practice of Anesthesiology.","author":"Van Hemelrijck J.","year":"1993"},{"key":"bibr17-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/68.1.114"},{"key":"bibr18-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/52.5.527"},{"key":"bibr19-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15633.x"},{"key":"bibr20-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199410000-00026"},{"key":"bibr21-0310057X9902700403","first-page":"1002","volume":"80","author":"Peacock J.E.","year":"1995","journal-title":"Anesth Analg"},{"key":"bibr22-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9101900110"},{"key":"bibr23-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199701000-00004"},{"key":"bibr24-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.4.375"},{"key":"bibr25-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197711000-00010"},{"key":"bibr26-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1990.tb14328.x"},{"key":"bibr27-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/67.3.281"},{"key":"bibr28-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.5.502"},{"key":"bibr29-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1991.tb09349.x"},{"key":"bibr30-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1996.tb07860.x"},{"key":"bibr31-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1985.tb10547.x"},{"key":"bibr32-0310057X9902700403","first-page":"35","volume":"69","author":"Brussel T.","year":"1989","journal-title":"Anesth Analg"},{"key":"bibr33-0310057X9902700403","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199105000-00002"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X9902700403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X9902700403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:04:39Z","timestamp":1777367079000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X9902700403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,8]]}},"alternative-id":["10.1177\/0310057X9902700403"],"URL":"https:\/\/doi.org\/10.1177\/0310057x9902700403","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,8]]}}}