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The question is complicated by the fact that pineal cysts are frequently found on brain magnetic resonance imaging. Much has been published about the possible role of benign pineal cysts in the pathophisiology of headaches and the potential of melatonin in headache therapy, as well as in other disorders. The aim of this article is to review the current state of the suject. We have tried to place accurately the relation between headache and pineal cysts based on the available evidence, as well as the actual role of melatonin in physiology and pharmacology, more specifically in headache therapy. We include a clinical case to illustrate the subject.<\/jats:p>","DOI":"10.1177\/0333102409359467","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T20:50:35Z","timestamp":1275511835000},"page":"1031-1040","source":"Crossref","is-referenced-by-count":6,"title":["Some questions provoked by a chronic headache (with mixed migraine and cluster headache features) in a woman with a pineal cyst. 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