{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:52:17Z","timestamp":1790041937714,"version":"4.0.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T00:00:00Z","timestamp":1269561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>Background: Riboflavin seems to have a promising effect on migraine in adults. The present study examines whether riboflavin has a prophylactic effect on migraine in children.<\/jats:p>\n                  <jats:p>Objective: To investigate whether riboflavin in a dosage of 50\u2009mg\/day has a prophylactic effect on migraine attacks in young children.<\/jats:p>\n                  <jats:p>Subjects and methods: This randomised, placebo-controlled, double-blind, cross-over trial included 42 children (aged 6\u201313 years) with migraine of whom 14 children were also suffering from tension-type headache. Following a 4-week baseline period, all children received placebo for 16 weeks then riboflavin for 16 weeks (or vice versa) with a washout period of 4 weeks in between. The primary outcome measure was reduction in mean frequency of migraine attacks and tension-type headache in the last 4 weeks at the end of the riboflavin and placebo phase, compared with the preceding baseline or wash-out period. Secondary outcome measures were mean severity and mean duration of migraine and tension-type headaches in the last 4 weeks at the end of the riboflavin and placebo phase, compared with the preceding baseline or wash-out period.<\/jats:p>\n                  <jats:p>Results: No significant difference in the reduction of mean frequency of migraine attacks in the last month of treatment was found between placebo and riboflavin ( P\u2009=\u20090.44). However, a significant difference in reduction of mean frequency of headaches with a tension-type phenotype was found in favour of the riboflavin treatment ( P\u2009=\u20090.04).<\/jats:p>\n                  <jats:p>Conclusions: In this group of children with migraine, there is no evidence that 50\u2009mg riboflavin has a prophylactic effect on migraine attacks. We found some evidence that 50\u2009mg riboflavin may have a prophylactic effect on interval headaches that may correspond to mild migraine attacks or tension-type headache attacks in children with migraine.<\/jats:p>","DOI":"10.1177\/0333102410365106","type":"journal-article","created":{"date-parts":[[2010,11,8]],"date-time":"2010-11-08T16:10:36Z","timestamp":1289232636000},"page":"1426-1434","source":"Crossref","is-referenced-by-count":94,"title":["Medium-dose riboflavin as a prophylactic agent in children with migraine: A preliminary placebo-controlled, randomised, double-blind, cross-over trial"],"prefix":"10.1177","volume":"30","author":[{"given":"Jacques","family":"Bruijn","sequence":"first","affiliation":[{"name":"Vlietland Hospital, Schiedam, The Netherlands."},{"name":"Sophia Children\u2019s Hospital, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Duivenvoorden","sequence":"additional","affiliation":[{"name":"Erasmus Medical Centre, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Passchier","sequence":"additional","affiliation":[{"name":"Erasmus Medical Centre, Rotterdam, The Netherlands."},{"name":"VU University, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Locher","sequence":"additional","affiliation":[{"name":"Sophia Children\u2019s Hospital, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascha","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Sophia Children\u2019s Hospital, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem-Frans","family":"Arts","sequence":"additional","affiliation":[{"name":"Sophia Children\u2019s Hospital, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,3,26]]},"reference":[{"key":"bibr1-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1983.hed2301015.x"},{"key":"bibr2-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2742"},{"key":"bibr3-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.01046.x"},{"key":"bibr4-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.01047.x"},{"key":"bibr5-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000147332.41993.90"},{"key":"bibr6-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0642"},{"key":"bibr7-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.4.538"},{"key":"bibr8-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.6.1209"},{"key":"bibr9-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.4.666"},{"key":"bibr10-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1023\/B:BOLI.0000037354.66587.38"},{"key":"bibr11-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1994.1405328.x"},{"key":"bibr12-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.2.466"},{"key":"bibr13-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2000.00005.x"},{"key":"bibr14-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00813.x"},{"key":"bibr15-0333102410365106","first-page":"1","volume":"24","author":"Headache Classification Committee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr16-0333102410365106","unstructured":"Bruijn J, Gooskens R, Verhagen A, Damen L, Passchier J. Evidence Based Guideline \u2018\n                      Migraine in Children\n                      \u2019 as part of Dutch National Guideline \u2018\n                      Pain Measurement and Treatment in Children\n                      \u2019. on-line publication March 2008; 53\u201365 <http:\/\/www.nvk.pedianet.nl\/pdfs\/nvk_richtlijn_pijn_bij_kinderen.pdf>"},{"key":"bibr17-0333102410365106","first-page":"41","volume-title":"Statistics in Practice","author":"Senn S","edition":"2"},{"key":"bibr18-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1053\/spen.2001.23330"},{"key":"bibr19-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1177\/0883073808318053"},{"key":"bibr20-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90618-9"},{"key":"bibr21-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04170.x"},{"key":"bibr22-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01752.x"},{"key":"bibr23-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a41269"},{"key":"bibr24-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-009-0142-2"},{"key":"bibr25-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01774.x"},{"key":"bibr26-0333102410365106","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.9_suppl_6.S27"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102410365106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102410365106","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102410365106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:44:12Z","timestamp":1777387452000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102410365106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,26]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1177\/0333102410365106"],"URL":"https:\/\/doi.org\/10.1177\/0333102410365106","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,26]]}}}