{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:18:56Z","timestamp":1792642736895,"version":"4.5.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2010,5,12]],"date-time":"2010-05-12T00:00:00Z","timestamp":1273622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>Introduction: Calcitonin gene-related peptide (CGRP) is a key molecule in migraine pathogenesis. Intravenous CGRP infusion triggers delayed migraine-like attacks in patients with migraine without aura (MO). In contrast to patients with MO, in prior studies patients with familial hemiplegic migraine (FHM) did not report more migraine-like attacks compared to controls. Whether CGRP triggers migraine in patients with typical (non-hemiplegic) migraine with aura is (MA) unknown. In the present study we examined the migraine inducing effect of CGRP infusion in patients suffering from MA and healthy controls.<\/jats:p>\n                  <jats:p>Methods: Fourteen patients suffering exclusively from migraine with typical aura (MA) and 11 healthy volunteers received a continuous intravenous infusion of 1.5\u2009\u00b5g\/min CGRP over 20 minutes. Headache and other migraine symptoms were scored every 10 minutes for one hour and self recorded hourly thereafter and until 13 hours post-infusion.<\/jats:p>\n                  <jats:p>Results: CGRP infusion induced significantly more delayed headaches in MA patients (12 out of 14) than in controls (2 out of 11) ( p\u2009=\u20090.001). Furthermore, significantly more MA patients (57%; 8 out of 14) fulfilled criteria for an experimentally induced migraine attack after CGRP than controls (0%; 0 out of 11) ( P\u2009=\u20090.003). Four patients (28%) reported aura symptoms after CGRP infusion.<\/jats:p>\n                  <jats:p>Conclusion: CGRP triggered migraine-like attacks without aura in patients suffering exclusively from MA. It also triggered a typical aura in 28% of the patients. These data indicate similar neurobiological pathways responsible for triggering migraine headache in MA and MO patients, and suggest differences between MA\/MO and FHM.<\/jats:p>","DOI":"10.1177\/0333102410368444","type":"journal-article","created":{"date-parts":[[2010,5,12]],"date-time":"2010-05-12T21:09:36Z","timestamp":1273698576000},"page":"1179-1186","source":"Crossref","is-referenced-by-count":456,"title":["Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura"],"prefix":"10.1177","volume":"30","author":[{"given":"Jakob M\u00f8ller","family":"Hansen","sequence":"first","affiliation":[{"name":"Glostrup Hospital and University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Werner","family":"Hauge","sequence":"additional","affiliation":[{"name":"Glostrup Hospital and University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes","family":"Olesen","sequence":"additional","affiliation":[{"name":"Glostrup Hospital and University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[{"name":"Glostrup Hospital and University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,5,12]]},"reference":[{"key":"bibr1-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.09.003"},{"key":"bibr2-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1038\/304129a0"},{"key":"bibr3-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1038\/308653a0"},{"key":"bibr4-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.15.5731"},{"key":"bibr5-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230214"},{"key":"bibr6-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00310.x"},{"key":"bibr7-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030505"},{"key":"bibr8-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000286940.29755.61"},{"key":"bibr9-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61626-8"},{"key":"bibr10-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp168"},{"key":"bibr11-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000325482.64106.3f"},{"issue":"1","key":"bibr12-0333102410368444","first-page":"9","volume":"24","author":"International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr13-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/110.4.917"},{"key":"bibr14-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1999.019008701.x"},{"key":"bibr15-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090406"},{"key":"bibr16-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.2.447"},{"key":"bibr17-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(89)90067-5"},{"key":"bibr18-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01172.x"},{"key":"bibr19-0333102410368444","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.10.001"},{"key":"bibr20-0333102410368444","unstructured":"Gore SM, Altman DG. 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