{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:28:46Z","timestamp":1780050526394,"version":"3.53.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T00:00:00Z","timestamp":1278028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Objective: Our objective was to study the long-term prognosis of sporadic hemiplegic migraine (SHM).<\/jats:p>\n                  <jats:p>Methods: We performed a longitudinal follow-up study in 18 patients who were diagnosed with SHM between 1993 and 1996. Follow-up time between the first and second survey ranged from nine to 14 years. These patients were included as part of a genetic study in which we systematically analysed the role of the three known familial hemiplegic migraine (FHM) genes.<\/jats:p>\n                  <jats:p>Results: In 12 out of 18 patients the clinical diagnosis was unchanged. In two of the six remaining patients the attacks were no longer associated with hemiplegia; one of them had an ATP1A2 gene mutation (E120A). In the four other patients, the diagnosis changed into FHM, because a family member had developed hemiplegic migraine since the initial diagnosis was made. In two of the four patients a mutation was demonstrated ( CACNA1A [R583Q] and ATP1A2 [R834X]).<\/jats:p>\n                  <jats:p>Conclusion: This study shows that the diagnosis of SHM changes into FHM in a considerable percentage of patients (22% [4 of 18]), almost a decade after the initial diagnosis. This indicates that a careful follow-up of SHM patients and their families is advisable for optimal care and counseling. Diagnostic screening of FHM genes in SHM patients can be of value. Our genetic and clinical follow-up studies reinforce the evidence that FHM and SHM are part of the same spectrum of migraine.<\/jats:p>","DOI":"10.1177\/0333102410375629","type":"journal-article","created":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T21:10:36Z","timestamp":1278105036000},"page":"199-205","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["A long-term follow-up study of 18 patients with sporadic hemiplegic migraine"],"prefix":"10.1177","volume":"31","author":[{"given":"Anine H","family":"Stam","sequence":"first","affiliation":[{"name":"Leiden University Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Louter","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Haan","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, The Netherlands."},{"name":"Rijnland Hospital, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boukje","family":"de Vries","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arn MJM","family":"van den Maagdenberg","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune R","family":"Frants","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel D","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela M","family":"Terwindt","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,7,2]]},"reference":[{"key":"bibr1-0333102410375629","first-page":"1","volume":"24","author":"Headache Classification Subcommittee of the International Headache 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