{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:36:38Z","timestamp":1792614998129,"version":"4.5.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T00:00:00Z","timestamp":1288310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>\n                    Background: Among serotonin receptors, 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    receptors are implicated in the regulation of central serotoninergic tone and could be involved in the abnormal brain 5-HT turnover suspected in migraineurs. The aim of this study was to investigate 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    receptors\u2019 availability during migraine attacks.\n                  <\/jats:p>\n                  <jats:p>\n                    Methods: Ten patients suffering from odor-triggered migraine attacks and 10 control subjects were investigated using positron emission tomography (PET) and [\n                    <jats:sup>18<\/jats:sup>\n                    F]MPPF PET tracer, a selective 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    antagonist. All subjects underwent calibrated olfactory stimulations prior to the PET study.\n                  <\/jats:p>\n                  <jats:p>\n                    Results: Four patients developed a migraine attack during the PET study. In these patients, statistical parametrical mapping and region of interest analyses showed an increased [\n                    <jats:sup>18<\/jats:sup>\n                    F]MPPF binding potential (BP\n                    <jats:sub>ND<\/jats:sub>\n                    ) in the pontine raphe when compared to headache-free migraineurs and control subjects. This ictal change was confirmed at the individual level in each of the four affected patients. In comparison with the headache-free migraineurs, patients with a migraine attack also showed significantly increased [\n                    <jats:sup>18<\/jats:sup>\n                    F]MPPF BP\n                    <jats:sub>ND<\/jats:sub>\n                    in the left orbitofrontal cortex, precentral gyrus and temporal pole. No significant change in [\n                    <jats:sup>18<\/jats:sup>\n                    F]MPPF BP\n                    <jats:sub>ND<\/jats:sub>\n                    was observed between headache-free migraineurs and controls.\n                  <\/jats:p>\n                  <jats:p>\n                    Conclusions: Our results emphasize the role of 5HT\n                    <jats:sub>1A<\/jats:sub>\n                    receptors in the pontine raphe nuclei during the early stage of migraine attacks.\n                  <\/jats:p>","DOI":"10.1177\/0333102410385581","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T20:45:51Z","timestamp":1288385151000},"page":"84-94","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["Brainstem changes in 5-HT\n                    <sub>1A<\/sub>\n                    receptor availability during migraine attack"],"prefix":"10.1177","volume":"31","author":[{"given":"G","family":"Demarquay","sequence":"first","affiliation":[{"name":"H\u00f4pital de la Croix-Rousse France."},{"name":"Institut National de la Sant\u00e9 et de la R\u00e9cherche M\u00e9dicale (INSERM 821) and Universit\u00e9 Lyon I, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lothe","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la R\u00e9cherche M\u00e9dicale (INSERM 821) and Universit\u00e9 Lyon I, France."},{"name":"Centre d\u2019Explorations et de Recherches M\u00e9dicales par Emission de Positons, France."},{"name":"CTRS-INSERM IDEE, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JP","family":"Royet","sequence":"additional","affiliation":[{"name":"Centre d\u2019Explorations et de Recherches M\u00e9dicales par Emission de Positons, France."},{"name":"Universit\u00e9 de St \u00c9tienne, UMR CNRS 5020 Universit\u00e9 Lyon 1, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Costes","sequence":"additional","affiliation":[{"name":"Centre d\u2019Explorations et de Recherches M\u00e9dicales par Emission de Positons, France."},{"name":"Universit\u00e9 de St \u00c9tienne, UMR CNRS 5020 Universit\u00e9 Lyon 1, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Mick","sequence":"additional","affiliation":[{"name":"INSERM U879 Universit\u00e9 Lyon 1 & Universit\u00e9 de St \u00c9tienne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Maugui\u00e8re","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de St \u00c9tienne, UMR CNRS 5020 Universit\u00e9 Lyon 1, France."},{"name":"INSERM U879 Universit\u00e9 Lyon 1 & Universit\u00e9 de St \u00c9tienne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ryvlin","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la R\u00e9cherche M\u00e9dicale (INSERM 821) and Universit\u00e9 Lyon I, France."},{"name":"Centre d\u2019Explorations et de Recherches M\u00e9dicales par Emission de Positons, France."},{"name":"CTRS-INSERM IDEE, France."},{"name":"INSERM U879 Universit\u00e9 Lyon 1 & Universit\u00e9 de St \u00c9tienne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,10,29]]},"reference":[{"key":"bibr1-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01476.x"},{"key":"bibr2-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1239"},{"key":"bibr3-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1404"},{"key":"bibr4-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2008.07.006"},{"key":"bibr5-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0444-0"},{"key":"bibr6-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1038\/nm0795-658"},{"key":"bibr7-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04250-1"},{"key":"bibr8-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh416"},{"key":"bibr9-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.8.1270"},{"key":"bibr10-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00776.x"},{"key":"bibr11-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000299095.65331.6f"},{"key":"bibr12-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(85)90156-1"},{"key":"bibr13-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01607-7"},{"key":"bibr14-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199808030-00033"},{"key":"bibr15-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00441.x"},{"key":"bibr16-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00335-4"},{"key":"bibr17-0333102410385581","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01677.x"},{"key":"bibr18-0333102410385581","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1468-2982.2003.00824.x","volume":"24","author":"Headache 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