{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:04:26Z","timestamp":1790143466561,"version":"4.0.1"},"reference-count":69,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T00:00:00Z","timestamp":1296604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>\n                    Background: Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy (\n                    <jats:sup>31<\/jats:sup>\n                    P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-state brain energy metabolism in patients with migraine without aura (MwoA) compared to control subjects by\n                    <jats:sup>31<\/jats:sup>\n                    P-MRS at 3 tesla.\n                  <\/jats:p>\n                  <jats:p>Methods: Quantification was performed using the phantom replacement technique. MRS measurements were performed interictally and in the medial occipital lobe of 19 MwoA patients and 26 age-matched controls.<\/jats:p>\n                  <jats:p>\n                    Results: A significantly decreased phosphocreatine concentration ([PCr]) was found as in previous studies. While adenosine triphosphate concentration ([ATP]) was considered to be constant in previously published work, this study found a significant decrease in the measured [ATP] in MwoA patients. The inorganic phosphate ([P\n                    <jats:sub>i<\/jats:sub>\n                    ]) and magnesium ([Mg\n                    <jats:sup>2+<\/jats:sup>\n                    ]) concentrations were not significantly different between MwoA patients and controls.\n                  <\/jats:p>\n                  <jats:p>Conclusions: The altered metabolic concentrations indicate that the energy metabolism in MwoA patients is impaired, certainly in a subgroup of patients. The actual decrease in [ATP] adds further strength to the theory of the presence of a mitochondrial component in the pathophysiology of migraine.<\/jats:p>","DOI":"10.1177\/0333102410394675","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T21:38:59Z","timestamp":1296682739000},"page":"1243-1253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":100,"title":["<sup>31<\/sup>\n                    P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients"],"prefix":"10.1177","volume":"31","author":[{"given":"Harmen","family":"Reyngoudt","sequence":"first","affiliation":[{"name":"Ghent University, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Paemeleire","sequence":"additional","affiliation":[{"name":"Ghent University, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicte","family":"Descamps","sequence":"additional","affiliation":[{"name":"Ghent University, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"De Deene","sequence":"additional","affiliation":[{"name":"Ghent University, Belgium."},{"name":"Sherbrooke University, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Achten","sequence":"additional","affiliation":[{"name":"Ghent University, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,2,2]]},"reference":[{"key":"bibr1-0333102410394675","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01288.x"},{"key":"bibr2-0333102410394675","unstructured":"Classification Committee of the International Headache Society. 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