{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:13:22Z","timestamp":1777490002952,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T00:00:00Z","timestamp":1303344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Background: There are no reports on the risk of stroke after trigeminal neuralgia (TN). The aim of this population-based follow-up study was to investigate whether the occurrence of TN is associated with a higher risk of developing stroke.<\/jats:p>\n                  <jats:p>Methods: A total of 1453 people with at least three ambulatory visits in 2001 with the principal diagnosis of TN were enrolled in the TN cohort. The non-TN cohort consisted of 5812 age- and sex-matched, randomly sampled subjects without TN. The 2-year stroke-free survival rate between the two groups was compared using the Kaplan-Meier method. The Cox proportional hazards regression model was used to estimate the hazard ratio of stroke after adjustment for demographic and clinical covariates.<\/jats:p>\n                  <jats:p>Results: In the TN cohort, 73 patients developed stroke during follow-up, while in the non-TN cohort, 157 subjects suffered a stroke. The crude hazard ratio of stroke for the subjects with TN was 1.86 (95% CI, 1.41\u20132.45; p\u2009&lt;\u20090.0001). The adjusted hazard ratio was 1.76 (95% CI, 1.33\u20132.33; p\u2009&lt;\u20090.0001) after adjusting for demographic characteristics and comorbid medical disorders.<\/jats:p>\n                  <jats:p>Conclusion: This study showed a significantly increased risk of developing stroke after TN. Further studies are needed to investigate the underlying mechanism of this association.<\/jats:p>","DOI":"10.1177\/0333102411405225","type":"journal-article","created":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T23:13:09Z","timestamp":1303427589000},"page":"937-942","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Increased risk of stroke after trigeminal neuralgia \u2013 a population-based follow-up study"],"prefix":"10.1177","volume":"31","author":[{"given":"Shin-Liang","family":"Pan","sequence":"first","affiliation":[{"name":"National Taiwan University Hospital, Taiwan."},{"name":"National Taiwan University College of Medicine, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Taipei Medical University, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Fang","family":"Yen","sequence":"additional","affiliation":[{"name":"Taipei Medical University, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueh-Hsia","family":"Chiu","sequence":"additional","affiliation":[{"name":"Chang Gung University, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Hsi","family":"Chen","sequence":"additional","affiliation":[{"name":"National Taiwan University, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,4,21]]},"reference":[{"issue":"1","key":"bibr1-0333102411405225","first-page":"9","volume":"24","author":"Headache Classification Subcommittee of the International Headache 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