{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:05:39Z","timestamp":1780347939390,"version":"3.54.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T00:00:00Z","timestamp":1310947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>Introduction: Familial hemiplegic migraine (FHM) is characterized by the familial occurrence of migraine attacks with fully reversible transient hemiplegia. Mutations in three different genes have been identified; CACNA1A (FHM1), ATP1A2 (FHM2) and SCN1A (FHM3). Besides hemiplegia, several other symptoms have been described in FHM 1\u20133 mutation carriers, including epilepsy and cerebellar symptoms.<\/jats:p>\n                  <jats:p>Case report: We describe two patients in whom hemiplegic attacks were not the presenting symptom, but in whom an otherwise unexplained head tremor led us to search for FHM mutations. Both patients carried a mutation in the CACNA1A gene.<\/jats:p>\n                  <jats:p>Discussion: CACNA1A mutations can give significant symptoms other than (hemiplegic) migraine as reason for presentation.<\/jats:p>","DOI":"10.1177\/0333102411414442","type":"journal-article","created":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T21:47:11Z","timestamp":1311025631000},"page":"1315-1319","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Head tremor related to\n                    <i>CACNA1A<\/i>\n                    mutations"],"prefix":"10.1177","volume":"31","author":[{"given":"Rianne PJ","family":"Geerlings","sequence":"first","affiliation":[{"name":"Atrium Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Koehler","sequence":"additional","affiliation":[{"name":"Atrium Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle YP","family":"Haane","sequence":"additional","affiliation":[{"name":"Atrium Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anine H","family":"Stam","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boukje","family":"de Vries","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elles MJ","family":"Boon","sequence":"additional","affiliation":[{"name":"Leiden University, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Haan","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre, The Netherlands."},{"name":"Rijnland Hospital Leiderdorp, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,7,18]]},"reference":[{"issue":"1","key":"bibr1-0333102411414442","first-page":"9","volume":"24","author":"Headache Classification Committee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr2-0333102411414442","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000133301.66364.9B"},{"key":"bibr3-0333102411414442","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3282fd171a"},{"key":"bibr4-0333102411414442","first-page":"577","volume-title":"The Headaches","author":"Ducros 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