{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:56Z","timestamp":1787018816493,"version":"build-2736575974"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T00:00:00Z","timestamp":1326672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>Objectives: To examine the association of genetic variants in the syntaxin 1A gene (STX1A) with common forms of migraine, and perform a combined analysis of the data from the current study and previously published reports.<\/jats:p>\n                  <jats:p>Methods: We investigated the parent-to-offspring transmission of rs6951030, rs4363087 and rs2293489 in 191 family trios, each with a proband with childhood-onset migraine, and performed a case-control analysis between the probands and 223 unrelated controls. In addition, we performed a combined data analysis with an overall sample of 567 migraine patients and 720 unrelated controls and performed a migraine-specific gene-network analysis.<\/jats:p>\n                  <jats:p>Results: The transmission disequilibrium test revealed significant transmission distortion of rs4363087 in migraine overall (OR\u2009=\u20091.56, p\u2009=\u20090.006; p\u2009=\u20090.01 after correction for multiple testing) and migraine without aura (OR\u2009=\u20091.58, p\u2009=\u20090.01; corrected p\u2009=\u20090.04). Two-marker haplotype analysis revealed transmission distortion of A-G (rs6951030-rs4363087; OR\u2009=\u20091.47, p\u2009=\u20090.01) and A-C (rs4363087-rs2293489; OR\u2009=\u20090.66, p\u2009=\u20090.01). Combined analysis showed significant association of rs941298 with migraine overall (OR\u2009=\u20091.28, p\u2009=\u20090.004) and migraine without aura (OR\u2009=\u20091.3, p\u2009=\u20090.008). Network analysis identified 24 genes relating STX1A to other migraine candidate genes, including KCNK18 (TRESK channel) involved in the cytoplasmatic calcium signalling together with syntaxin 1A.<\/jats:p>\n                  <jats:p>Conclusion: Our results provide support for the hypothesis that STX1A represents a susceptibility gene for migraine.<\/jats:p>","DOI":"10.1177\/0333102411433300","type":"journal-article","created":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T21:17:58Z","timestamp":1326748678000},"page":"203-212","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Association analysis of STX1A gene variants in common forms of migraine"],"prefix":"10.1177","volume":"32","author":[{"given":"Maria","family":"Tropeano","sequence":"first","affiliation":[{"name":"Social, Genetic and Developmental Psychiatry Centre at the Institute of Psychiatry, King\u2019s College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7i\u00e7ek","family":"W\u00f6ber-Bing\u00f6l","sequence":"additional","affiliation":[{"name":"Headache Outpatient Centre, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Karwautz","sequence":"additional","affiliation":[{"name":"Headache Outpatient Centre, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Wagner","sequence":"additional","affiliation":[{"name":"Headache Outpatient Centre, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Vassos","sequence":"additional","affiliation":[{"name":"Social, Genetic and Developmental Psychiatry Centre at the Institute of Psychiatry, King\u2019s College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Campos-de-Sousa","sequence":"additional","affiliation":[{"name":"Social, Genetic and Developmental Psychiatry Centre at the Institute of Psychiatry, King\u2019s College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Graggaber","sequence":"additional","affiliation":[{"name":"Headache Outpatient Centre, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi E","family":"Zesch","sequence":"additional","affiliation":[{"name":"Headache Outpatient Centre, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kienbacher","sequence":"additional","affiliation":[{"name":"Headache Outpatient Centre, Department of 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A","family":"Collier","sequence":"additional","affiliation":[{"name":"Social, Genetic and Developmental Psychiatry Centre at the Institute of Psychiatry, King\u2019s College London, 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