{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:14:12Z","timestamp":1777490052482,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T00:00:00Z","timestamp":1340928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Background: Evidence for optimal medication-overuse headache treatment is lacking. Some experts suggest reduced symptomatic medication with prophylactics from the start of withdrawal, while others suggest a two-month drug-free period with multidisciplinary education.<\/jats:p>\n                  <jats:p>Aim: To examine the acceptability, feasibility and outcome of these two regimes in a non-randomised open-label study.<\/jats:p>\n                  <jats:p>Methods: Patients able to undergo outpatient detoxification, with medication-overuse headache that had previously been unsuccessfully treated by specialists and without significant co-morbidities were treated with (A) individual withdrawal with restricted symptomatic medication and prophylactics from Day 1 or (B) a two-month drug-free period and multidisciplinary education in groups. All patients received close one-year follow-up.<\/jats:p>\n                  <jats:p>Results: Eighty-six of 98 patients completed follow-up. Both treatments proved highly effective\u201480.0% of Group A and 85.4% of Group B were cured of medication-overuse headache. Headache-frequency reduction was 40.2% in Group A and 38.4% in group B. In 48.9% of group A and 48.8% of group B, headache-frequency reduction was &gt;50%. Programme B required fewer resources from the staff and only 61.9% of these patients needed prophylactics after two months compared with 84.8% in programme A.<\/jats:p>\n                  <jats:p>Conclusions: Both structured detoxification programmes proved highly effective with one-year close follow-up in previously treatment-resistant patients with medication-overuse headache. We suggest multidisciplinary education for patients in groups and delaying initiation of prophylactics until after the detoxification.<\/jats:p>","DOI":"10.1177\/0333102412451363","type":"journal-article","created":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T22:25:24Z","timestamp":1341008724000},"page":"834-844","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":62,"title":["Detoxification of medication-overuse headache by a multidisciplinary treatment programme is highly effective: A comparison of two consecutive treatment methods in an open-label design"],"prefix":"10.1177","volume":"32","author":[{"given":"Signe B","family":"Munksgaard","sequence":"first","affiliation":[{"name":"Danish Headache Centre, University of Copenhagen, Glostrup Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Danish Headache Centre, University of Copenhagen, Glostrup Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rigmor H","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Headache Centre, University of Copenhagen, Glostrup Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,6,29]]},"reference":[{"key":"bibr1-0333102412451363","doi-asserted-by":"publisher","DOI":"10.1007\/s004820050185"},{"key":"bibr2-0333102412451363","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000217914.30994.bd"},{"key":"bibr3-0333102412451363","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01172.x"},{"key":"bibr4-0333102412451363","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70008-9"},{"key":"bibr5-0333102412451363","first-page":"971","volume-title":"The headaches","author":"Diener 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