{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:36:19Z","timestamp":1790876179577,"version":"4.1.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T00:00:00Z","timestamp":1350950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the efficacy of prednisone for treatment of withdrawal headache in patients with medication overuse headache (MOH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>In this prospective double-blind, placebo-controlled, parallel designed multicentre trial, 96 consecutive patients with MOH were randomized to withdrawal treatment with either 100\u2009mg prednisone or placebo over 5 days. Patients were enrolled if they met the International Headache Society criteria for MOH and were diagnosed with migraine or episodic tension-type headache as primary headache. Exclusion criteria comprised significant neurological or psychiatric disorders. Withdrawal symptoms, including headache severity and intake of rescue medication, were documented for 14 days after randomization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients treated with prednisone did not experience fewer hours of moderate or severe headache than patients receiving placebo. However, patients requested less rescue medication within the first 5 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>During withdrawal in MOH, prednisone reduces rescue medication without decreasing the severity and duration of withdrawal headache.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102412462638","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T00:45:02Z","timestamp":1351039502000},"page":"202-207","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":76,"title":["Prednisone for the treatment of withdrawal headache in patients with medication overuse headache: A randomized, double-blind, placebo-controlled study"],"prefix":"10.1177","volume":"33","author":[{"given":"Kasja","family":"Rabe","sequence":"first","affiliation":[{"name":"Department of Neurology and Headache Center, University Duisburg- Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Pageler","sequence":"additional","affiliation":[{"name":"Department of Neurology and Headache Center, University Duisburg- Essen, Germany"},{"name":"Department of Neurology, Cologne City Hospitals, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charly","family":"Gaul","sequence":"additional","affiliation":[{"name":"Department of Neurology and Headache Center, University Duisburg- Essen, Germany"},{"name":"Department of Neurology, Luther-University Halle-Wittenberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lampl","sequence":"additional","affiliation":[{"name":"Department of Neurology and Pain Medicine, Upper Austrian Headache Centre, Konventhospital Barmherzige Brueder, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Kraya","sequence":"additional","affiliation":[{"name":"Department of Neurology, Luther-University Halle-Wittenberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Foerderreuther","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians-University, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Christoph","family":"Diener","sequence":"additional","affiliation":[{"name":"Department of Neurology and Headache Center, University Duisburg- Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaza","family":"Katsarava","sequence":"additional","affiliation":[{"name":"Department of Neurology and Headache Center, University Duisburg- Essen, Germany"},{"name":"Department of Neurology, Evangelisches Krankenhaus Unna, 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