{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:58:52Z","timestamp":1791435532973,"version":"4.3.3"},"reference-count":40,"publisher":"SAGE Publications","issue":"16","license":[{"start":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T00:00:00Z","timestamp":1349913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of this article is to generate hypotheses for the mechanism of pituitary adenoma headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>Fifty-eight patients with pituitary adenoma were prospectively analysed for prevalence and manifestation of tumour headache. Intrapersonal and neoplasm-associated risk factors were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-four patients (41%) had tumour-attributed headache, seven had migraine-like, 11 tension-type headache-like headache, and three both. Cluster headache-like headache was found once, and two headaches remained unclassified. Tumour-attributed headache was associated with a positive history of headache ( p\u2009=\u20090.03; OR 3.4), nicotine abuse ( p\u2009&lt;\u20090.01; OR 4.7), intake of acute headache medication ( p\u2009=\u20090.04; OR 3.3), and a higher tumour proliferation indicated by a Ki67-labelling index (LI) &gt;3% ( p\u2009=\u20090.02; OR 11.0). For patients with migraine-like tumour-attributed headache, risk factors were younger age ( p\u2009=\u20090.02), nicotine abuse ( p\u2009&lt;\u20090.01; OR 10.9), acute headache treatment ( p\u2009&lt;\u20090.01; OR 9.0), and Ki67-LI &gt;3% ( p\u2009=\u20090.03; OR 14.1). For tension-type headache-like headache, the main risk factor was a positive history of tension-type headache ( p\u2009=\u20090.045; OR 5.6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Headache predisposition and local tumour effects might be important for the pathophysiology of pituitary adenoma headache and tumour headache in general.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102412462639","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T22:51:11Z","timestamp":1349995871000},"page":"1198-1207","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Headache in patients with pituitary adenoma: Clinical and paraclinical findings"],"prefix":"10.1177","volume":"32","author":[{"given":"Christoph 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