{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:22:01Z","timestamp":1777490521349,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate factors associated with a negative outcome in a 3-year follow-up of subjects diagnosed with medication-overuse headache (MOH) (revised-ICHD-II criteria).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All consecutive patients entering the center\u2019s inpatient detoxification program were analyzed in a prospective, non-randomized fashion. All participants were assessed by a neurologist using an ad hoc patient record form. Personality was assessed using the Minnesota Multiphasic Personality Inventory (MMPI)-2, Chi-square test, one-way analysis of variance (ANOVA), and odds ratios (OR) were calculated as appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One-hundred and fifty patients completed the follow-up (79.3% females, age 46.40\u2009\u00b1\u200911.31 years): 13 never stopped their drug overuse (A), 38 stopped their overuse, but relapsed at least once (B), and 99 stopped and never relapsed (C). The Group A patients differed from those in B\u2009+\u2009C as they were more frequently single (OR 0.134; p\u2009=\u20090.007) and unemployed (OR 3.273; p\u2009=\u20090.04), took a higher number of drug doses ( p\u2009&lt;\u20090.001), and less frequently drank coffee (OR 3.273; p\u2009=\u20090.044). Personality profile: subjects in A scored higher than those in C on the following scales: Hypochondriasis ( p\u2009=\u20090.007), Depression ( p\u2009=\u20090.003), Paranoia ( p\u2009=\u20090.025), Fears ( p\u2009=\u20090.003), Obsessiveness ( p\u2009=\u20090.026), Bizarre Mentation ( p\u2009=\u20090.046), Social Discomfort ( p\u2009=\u20090.004), Negative Treatment Indicators ( p\u2009=\u20090.040), Repression ( p\u2009=\u20090.007), Overcontrolled Hostility ( p\u2009=\u20090.040), Addiction Admission ( p\u2009=\u20090.021), Social Responsibility ( p\u2009=\u20090.039), and Marital Distress ( p\u2009=\u20090.028).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Disease outcome in MOH patients is influenced negatively by overuse severity and by specific psychological and socio-economic variables. Other possible modifier factors were voluptuary habits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102413477737","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T05:52:43Z","timestamp":1361944363000},"page":"431-443","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Factors associated with a negative outcome of medication-overuse headache: A 3-year follow-up (the \u2018CARE\u2019 protocol)"],"prefix":"10.1177","volume":"33","author":[{"given":"Grazia","family":"Sances","sequence":"first","affiliation":[{"name":"Headache Unit, C. Mondino National Institute of Neurology Foundation, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Galli","sequence":"additional","affiliation":[{"name":"Headache Science Center, C. Mondino National Institute of Neurology Foundation, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natascia","family":"Ghiotto","sequence":"additional","affiliation":[{"name":"Neurovascular Unit, C. Mondino National Institute of Neurology Foundation, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Allena","sequence":"additional","affiliation":[{"name":"Headache Science Center, C. Mondino National Institute of Neurology Foundation, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Guaschino","sequence":"additional","affiliation":[{"name":"Neurovascular Unit, C. 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Mondino National Institute of Neurology Foundation, Italy"},{"name":"University of Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"bibr1-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328136c21c"},{"key":"bibr2-0333102413477737","first-page":"1","volume":"24","author":"Headache Classification Subcommittee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr3-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00878.x"},{"key":"bibr4-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01172.x"},{"key":"bibr5-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70008-9"},{"key":"bibr6-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01183.x"},{"key":"bibr7-0333102413477737","first-page":"412","volume":"48","author":"Cevoli S","year":"2008","journal-title":"Headache"},{"key":"bibr8-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-009-0136-0"},{"key":"bibr9-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1996.1606419.x"},{"key":"bibr10-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh691"},{"key":"bibr11-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01457.x"},{"key":"bibr12-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00910.x"},{"key":"bibr13-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.02.014"},{"key":"bibr14-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01978.x"},{"key":"bibr15-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00999.x"},{"key":"bibr16-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.09.034"},{"key":"bibr17-0333102413477737","first-page":"201","volume":"22","author":"Evers S, Gralow B","year":"1999","journal-title":"Clin Neuropharmacol"},{"key":"bibr18-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.7.1011"},{"key":"bibr19-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01737.x"},{"key":"bibr20-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-005-0216-8"},{"key":"bibr21-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01175.x"},{"key":"bibr22-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00971.x"},{"key":"bibr23-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1981.tb00005.x"},{"key":"bibr24-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01659.x"},{"key":"bibr25-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02571.x"},{"key":"bibr26-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01934.x"},{"key":"bibr27-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01432.x"},{"key":"bibr28-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70008-9"},{"key":"bibr29-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00789.x"},{"key":"bibr30-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1996.1607481.x"},{"key":"bibr31-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-010-0285-1"},{"key":"bibr32-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-010-0221-4"},{"key":"bibr33-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000063322.14078.90"},{"key":"bibr34-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01155.x"},{"key":"bibr35-0333102413477737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01712.x"},{"key":"bibr36-0333102413477737","unstructured":"Mazzi F, Morosini P, De Girolamo G, et al.\n                      SCID-I CV\n                      : Italian Edition. 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