{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:23:43Z","timestamp":1777490623473,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to assess biochemical changes in the brain of patients with hemiplegic migraine in between attacks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighteen patients with hemiplegic migraine (M:F, 7:11; age 38\u2009\u00b1\u200914 years) of whom eight had a known familial hemiplegic migraine (FHM) mutation (five in the CACNA1A gene (FHM1), three in the ATP1A2 gene (FHM2)) and 19 age- and sex-matched healthy controls (M:F, 7:12; mean age 38\u2009\u00b1\u2009 12 years) were studied. We used single-voxel 7 tesla\n                      <jats:sup>1<\/jats:sup>\n                      H-MRS (STEAM, TR\/TM\/TE\u2009=\u20092000\/19\/21 ms) to investigate four brain regions in between attacks: cerebellum, hypothalamus, occipital lobe, and pons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with hemiplegic migraine showed a significantly lower total N-acetylaspartate\/total creatine ratio (tNAA\/tCre) in the cerebellum (median 0.73, range 0.59\u20131.03) than healthy controls (median 0.79, range (0.67\u20130.95); p = 0.02). In FHM1 patients with a CACNA1A mutation, the tNAA\/tCre was lowest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      We found a decreased cerebellar tNAA\/tCre ratio that might serve as an early biomarker for neuronal dysfunction and\/or loss. This is the first high-spectral resolution 7 tesla\n                      <jats:sup>1<\/jats:sup>\n                      H-MRS study of interictal biochemical brain changes in hemiplegic migraine patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102414527016","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T20:47:45Z","timestamp":1395348465000},"page":"959-967","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Biochemical changes in the brain of hemiplegic migraine patients measured with 7 tesla\n                    <sup>1<\/sup>\n                    H-MRS"],"prefix":"10.1177","volume":"34","author":[{"given":"R","family":"Zielman","sequence":"first","affiliation":[{"name":"Department of Neurology, Leiden University Medical Centre, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WM","family":"Teeuwisse","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Centre, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Bakels","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Centre, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Van der Grond","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Centre, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Centre, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MA","family":"van Buchem","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Centre, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MD","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Centre, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MC","family":"Kruit","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Centre, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GM","family":"Terwindt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Centre, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"bibr1-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf132"},{"key":"bibr2-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450103"},{"key":"bibr3-0333102414527016","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version).\n                      Cephalalgia\n                      2013; 33: 629\u2013808.","DOI":"10.1177\/0333102413485658"},{"key":"bibr4-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-009-0684-z"},{"key":"bibr5-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81373-2"},{"key":"bibr6-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1038\/ng1081"},{"key":"bibr7-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66786-4"},{"key":"bibr8-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-012-0208-3"},{"key":"bibr9-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00191-6"},{"key":"bibr10-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01983.x"},{"key":"bibr11-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3057"},{"key":"bibr12-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219042.60538.92"},{"key":"bibr13-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2006.12.003"},{"key":"bibr14-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1038\/350398a0"},{"key":"bibr15-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1031"},{"key":"bibr16-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000151855.98318.50"},{"key":"bibr17-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.11.1973"},{"key":"bibr18-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200206"},{"key":"bibr19-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1159\/000008123"},{"key":"bibr20-0333102414527016","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2387"},{"key":"bibr21-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420616"},{"key":"bibr22-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199908)46:2<256::AID-ANA17>3.0.CO;2-6"},{"key":"bibr23-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1078"},{"key":"bibr24-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-010-0213-6"},{"key":"bibr25-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-007-0776-2"},{"key":"bibr26-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-006-0589-8"},{"key":"bibr27-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412452048"},{"key":"bibr28-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.11.005"},{"key":"bibr29-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0295-7"},{"key":"bibr30-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-010-0221-z"},{"key":"bibr31-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.4.1093"},{"key":"bibr32-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00900.x"},{"key":"bibr33-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01979.x"},{"key":"bibr34-0333102414527016","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1529"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102414527016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102414527016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102414527016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:47:34Z","timestamp":1777387654000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102414527016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,20]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1177\/0333102414527016"],"URL":"https:\/\/doi.org\/10.1177\/0333102414527016","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,20]]}}}