{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:54:16Z","timestamp":1790024056694,"version":"4.0.1"},"reference-count":55,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Functional and structural disruptions to the pain matrix, which may involve changes in white matter (WM) pathways connecting the pain-processing system and hypothalamus, have been implicated in the pathophysiology of cluster headache (CH). However, previous studies have obtained inconclusive results regarding WM changes in CH, and WM variations between \u201cin-bout\u201d and \u201cout-of-bout\u201d periods of CH remain to be determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multiple diffusivity indices obtained by diffusion tensor imaging (DTI) and post-hoc probabilistic tractography were used to elucidate CH pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to healthy participants, in-bout CH patients showed regionally higher absolute (radial and mean) diffusivities in the left medial frontal gyrus and frontal sub-gyrus and lower absolute (axial, radial and mean) diffusivities in the right parahippocampal gyrus of the limbic lobe. These changes during the in-bout period generally persisted in the out-of-bout period, except for the left cerebellar tonsil. Post-hoc probabilistic tractography showed highly consistent anatomical connections between these altered areas and the hypothalamus across participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Distinct WM changes were observed in episodic CH. Connections between the pain-modulation areas and hypothalamus may be involved in CH pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102414527649","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T22:07:05Z","timestamp":1395785225000},"page":"1040-1052","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Altered white matter microstructural connectivity in cluster headaches: A longitudinal diffusion tensor imaging study"],"prefix":"10.1177","volume":"34","author":[{"given":"Kun-Hsien","family":"Chou","sequence":"first","affiliation":[{"name":"Institute of Neuroscience, National Yang-Ming University, Taiwan"},{"name":"Brain Research Center, National Yang-Ming University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Chi","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Brain Science, National Yang-Ming University, Taiwan"},{"name":"Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Ling","family":"Fuh","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Yang-Ming University, Taiwan"},{"name":"Department of Neurology, Taipei Veterans General Hospital, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Chung","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiing-Feng","family":"Lirng","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Yang-Ming University, Taiwan"},{"name":"Department of Radiology, Taipei, Veterans General Hospital, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Yang","family":"Lin","sequence":"additional","affiliation":[{"name":"Brain Research Center, National Yang-Ming University, Taiwan"},{"name":"Institute of Brain Science, National Yang-Ming University, Taiwan"},{"name":"Department of Neurology, National Yang-Ming University, Taiwan"},{"name":"Department of Neurology, Taipei Veterans General Hospital, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Lin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Wen","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Po","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, National Yang-Ming University, Taiwan"},{"name":"Brain Research Center, National Yang-Ming University, Taiwan"},{"name":"Institute of Brain Science, National Yang-Ming University, Taiwan"},{"name":"Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuu-Jiun","family":"Wang","sequence":"additional","affiliation":[{"name":"Brain Research Center, National Yang-Ming University, Taiwan"},{"name":"Institute of Brain Science, National Yang-Ming University, Taiwan"},{"name":"Department of Neurology, National Yang-Ming University, Taiwan"},{"name":"Department of Neurology, Taipei Veterans General Hospital, 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