{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:17:17Z","timestamp":1777490237964,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>The pathophysiology of tension-type headache is not well understood. Increased peripheral levels of pro-inflammatory cytokines may act as mediators of several chronic pain disorders. The aim of the present study was to investigate the peripheral levels of chemokines in patients with tension-type headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross sectional study evaluating serum levels of chemokines in age and sex-matched tension-type headache patients, ictally and interictally, and control participants. Beck Depression and Anxiety Inventories were recorded. Serum levels of monocyte chemoattractant protein-1, macrophage inflammatory protein 1\u03b1, regulated on activation, normal T cell expressed and secreted, eotaxin, eotaxin-2, interleukin-8, interferon gamma induced protein-10 were measured by enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 96 participants (48 tension-type headache, 48 controls) were included. Interleukin-8 levels were significantly increased in patients with tension-type headache when compared to controls (413.8 (123.4\u20131756.3) and 329 (107.8\u2013955.6), respectively, P\u2009=\u20090.025). Anxiety and depression scores were higher in patients with tension-type headache but interleukin-8 increase in tension-type headache patients persisted after controlling for anxiety and depression symptoms. Patients with headache at the time of assessment had increased monocyte chemoattractant protein-1 levels when compared with patients without headache (2809.3 (1101\u20136122.2) and 1630.2 (669.3\u201331056.8), respectively P\u2009=\u20090.026). Patients with episodic and chronic tension-type headache had no significant differences in serum chemokines levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Interleukin-8 was increased in tension-type headache and monocyte chemoattractant protein-1 was higher in tension-type headache patients with headache, suggesting that pro-inflammatory mechanisms may participate in tension-type headache pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102414559734","type":"journal-article","created":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T00:10:29Z","timestamp":1416615029000},"page":"801-806","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Increased serum levels of interleukin-8 in patients with tension-type headache"],"prefix":"10.1177","volume":"35","author":[{"given":"Renan B","family":"Domingues","sequence":"first","affiliation":[{"name":"Neurosciences Postgraduation Program, Federal University of Minas Gerais (UFMG), Brazil"},{"name":"CHRU, Pole Neurologie, Universit\u00e9 Lille 2, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halina","family":"Duarte","sequence":"additional","affiliation":[{"name":"Neurosciences Postgraduation Program, Federal University of Minas Gerais (UFMG), Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia P","family":"Rocha","sequence":"additional","affiliation":[{"name":"Interdisciplinar Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais (UFMG), Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio L","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Neurosciences Postgraduation Program, Federal University of Minas Gerais (UFMG), Brazil"},{"name":"Interdisciplinar Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais (UFMG), Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,11,21]]},"reference":[{"key":"bibr1-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.5.381"},{"key":"bibr2-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2000.00070.x"},{"key":"bibr3-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2008.11.010"},{"key":"bibr4-0333102414559734","doi-asserted-by":"publisher","DOI":"10.2174\/092986708786242822"},{"key":"bibr5-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.06.007"},{"key":"bibr6-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2012.12.003"},{"key":"bibr7-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2011.12.007"},{"key":"bibr8-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-012-0327-6"},{"key":"bibr9-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-44462012000100013"},{"key":"bibr10-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181e8d9b6"},{"key":"bibr11-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/796161"},{"key":"bibr12-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052723"},{"key":"bibr13-0333102414559734","unstructured":"Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition.\n                      Cephalalgia\n                      2004; 24 Suppl. 1: 9\u2013160."},{"key":"bibr14-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.893"},{"key":"bibr15-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"bibr16-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.11.019"},{"key":"bibr17-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.240"},{"key":"bibr18-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32830eb69d"},{"key":"bibr19-0333102414559734","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00034"},{"key":"bibr20-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00722.x"},{"key":"bibr21-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-010-0233-0"},{"key":"bibr22-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.10.005"},{"key":"bibr23-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01727.x"},{"key":"bibr24-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00520.x"},{"key":"bibr25-0333102414559734","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-1591(02)00021-1"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102414559734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102414559734","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102414559734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:46:38Z","timestamp":1777387598000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102414559734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,21]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1177\/0333102414559734"],"URL":"https:\/\/doi.org\/10.1177\/0333102414559734","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,21]]}}}