{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:37:26Z","timestamp":1777603046943,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Evidence on the association between headache and physical fitness is conflicting. The aim of this population-based study was to examine the relationship between peak oxygen uptake (VO\n                      <jats:sub>2peak<\/jats:sub>\n                      ) and headache, including migraine and tension-type headache (TTH).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In the third Nord-Tr\u00f8ndelag Health study (HUNT3), VO\n                      <jats:sub>2peak<\/jats:sub>\n                      was measured by ergospirometry in a sample of 4631 healthy adult participants. Of these, 3899 (54% women) also answered headache questions. The cross-sectional association between headache and VO\n                      <jats:sub>2peak<\/jats:sub>\n                      was evaluated by logistic regression using a categorical approach based on quintiles. Scores in the upper quintile were used as reference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants age 20\u201350 years had significant trends of increasing prevalence of any headache ( p\u2009&lt;\u20090.001), migraine ( p\u2009&lt;\u20090.001), TTH ( p\u2009=\u20090.002) and unclassified headache ( p\u2009=\u20090.027) with lower VO\n                      <jats:sub>2peak<\/jats:sub>\n                      . The highest prevalence odds ratios (ORs) were found in those with VO\n                      <jats:sub>2peak<\/jats:sub>\n                      in the lower quintile: For any headache the OR was 2.3 (95% confidence interval (1.6\u20133.3), for TTH 1.8 (1.2\u20132.8), for unclassified headache 1.9 (1.1\u20133.8), and for migraine 3.7 (2.1\u20136.6). Similar results were also found among those who reported physical activity levels in accordance with current recommendations of the American College of Sports Medicine but nevertheless had low VO\n                      <jats:sub>2peak<\/jats:sub>\n                      . Being in the lowest VO\n                      <jats:sub>2peak<\/jats:sub>\n                      quintile was also strongly associated with migraine aggravated by physical activity (OR 4.1, 2.1\u20138.1). No significant association was found between VO\n                      <jats:sub>2peak<\/jats:sub>\n                      and headache for those 50 years or older.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this large cross-sectional study, an inverse relationship was found between VO\n                      <jats:sub>2peak<\/jats:sub>\n                      and headache for adults younger than 50 years of age.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102415597528","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T22:10:37Z","timestamp":1437689437000},"page":"437-444","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Headache and peak oxygen uptake: The HUNT3 study"],"prefix":"10.1177","volume":"36","author":[{"given":"Knut","family":"Hagen","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Norwegian University of Science and Technology, Norway"},{"name":"Norwegian Advisory Unit on Headaches, St Olavs Hospital, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrik","family":"Wisl\u00f8ff","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Norway"},{"name":"Department of Cardiology, St Olavs Hospital, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8yvind","family":"Ellingsen","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Norway"},{"name":"Department of Cardiology, St Olavs Hospital, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars Jacob","family":"Stovner","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Norwegian University of Science and Technology, Norway"},{"name":"Norwegian Advisory Unit on Headaches, St Olavs Hospital, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Linde","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Norwegian University of Science and Technology, Norway"},{"name":"Norwegian Advisory Unit on Headaches, St Olavs Hospital, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"key":"bibr1-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e3282f232ac"},{"key":"bibr2-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199811000-00011"},{"key":"bibr3-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60749-6"},{"key":"bibr4-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61031-9"},{"key":"bibr5-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-013-0380-5"},{"key":"bibr6-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60898-8"},{"key":"bibr7-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01678.x"},{"key":"bibr8-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20140148"},{"key":"bibr9-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-46"},{"key":"bibr10-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-11"},{"key":"bibr11-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411419681"},{"key":"bibr12-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2008.01231.x"},{"key":"bibr13-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys095"},{"key":"bibr14-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31820ca81c"},{"key":"bibr15-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-143"},{"issue":"1","key":"bibr16-0333102415597528","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1468-2982.2004.00647.x","volume":"24","author":"Headache Classification Committee of the International Headache Society (IHS)","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr17-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410391488"},{"key":"bibr18-0333102415597528","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-009-0174-7"},{"key":"bibr19-0333102415597528","unstructured":"American College of Sports Medicine. ACSM\u2019s guidelines for exercise testing and prescription, 8th edn. 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