{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:06:55Z","timestamp":1789992415507,"version":"4.0.1"},"reference-count":52,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Though migraine is disabling and affects 12%\u201315% of the population, there are few drugs that have been developed specifically for migraine prevention. Valproic acid (VPA) is a broad-spectrum antiepileptic drug (AED) that is also used for migraine prophylaxis, but its clinical use is limited by its side effect profile. sec-Butylpropylacetamide (SPD) is a novel VPA derivative, designed to be more potent and tolerable than VPA, that has shown efficacy in animal seizure and pain models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated SPD\u2019s antimigraine potential in the cortical spreading depression (CSD) and nitroglycerin (NTG) models of migraine. To evaluate SPD\u2019s mechanism of action, we performed whole-cell recordings on cultured cortical neurons and neuroblastoma cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the CSD model, the SPD-treated group showed a significantly lower median number of CSDs compared to controls. In the NTG-induced mechanical allodynia model, SPD dose-dependently reduced mechanical sensitivity compared to controls. SPD showed both a significant potentiation of GABA-mediated currents and a smaller but significant decrease in NMDA currents in cultured cortical neurons. Kainic acid-evoked currents and voltage-dependent sodium channel currents were not changed by SPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results demonstrate SPD\u2019s potential as a promising novel antimigraine compound, and suggest a GABAergic mechanism of action.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102415612773","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T20:08:46Z","timestamp":1447531726000},"page":"924-935","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["<i>sec<\/i>\n                    -Butylpropylacetamide (SPD) has antimigraine properties"],"prefix":"10.1177","volume":"36","author":[{"given":"Dan","family":"Kaufmann","sequence":"first","affiliation":[{"name":"Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, USA"},{"name":"Department of Neurology, University of Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A","family":"Bates","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado Denver School of Medicine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Yagen","sequence":"additional","affiliation":[{"name":"Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Israel"},{"name":"David R. 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