{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:15:44Z","timestamp":1793276144268,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The development of novel migraine therapies has been slow, in part because of the small number of clinically relevant animal models. We have recently developed a new mouse model of chronic migraine using chronic intermittent nitroglycerin, a known human migraine trigger. The objective of this study was to validate this model by testing known and potential migraine-preventive treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Migraine therapies were administered to male and female mice for 11 days. On day 3, mice were tested with nitroglycerin every second day for nine days. Basal and nitroglycerin-evoked mechanical hypersensitivity was evaluated using von Frey filaments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Chronic intermittent nitroglycerin produced acute hyperalgesia with each administration, and progressive and sustained basal hypersensitivity. The established preventive migraine therapy propranolol effectively blocked the development of acute and chronic nitroglycerin-induced hyperalgesia, while valproate had no effect. Potential migraine-preventive therapies were also tested: Amiloride inhibited nitroglycerin-induced acute and chronic hyperalgesia; while memantine was ineffective. We also tested the acute migraine therapy sumatriptan, which did not alter nitroglycerin-induced hyperalgesia, but instead resulted in acute and chronic hyperalgesia similar to that observed following nitroglycerin administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study establishes the chronic nitroglycerin model as an additional screening tool to test novel migraine-preventive therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102415623070","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T20:27:15Z","timestamp":1450470435000},"page":"1048-1056","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":78,"title":["The effects of acute and preventive migraine therapies in a mouse model of chronic migraine"],"prefix":"10.1177","volume":"36","author":[{"given":"Alycia F","family":"Tipton","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Illinois at Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igal","family":"Tarash","sequence":"additional","affiliation":[{"name":"Headache Research and Treatment Program, Department of Neurology, David Geffen School of Medicine, UCLA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenna","family":"McGuire","sequence":"additional","affiliation":[{"name":"Headache Research and Treatment Program, Department of Neurology, David Geffen School of Medicine, UCLA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Charles","sequence":"additional","affiliation":[{"name":"Headache Research and Treatment Program, Department of Neurology, David Geffen School of Medicine, UCLA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amynah A","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Illinois at Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"bibr1-0333102415623070","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000323925.29520.e7"},{"key":"bibr2-0333102415623070","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1416"},{"key":"bibr3-0333102415623070","doi-asserted-by":"crossref","unstructured":"The International Classification of Headache Disorders, 3rd edition (beta version).\n                      Cephalalgia\n                      2013; 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