{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:22:18Z","timestamp":1777490538621,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The pathophysiology of reversible cerebral vasoconstriction syndrome (RCVS) is not known. Published cases have documented coexisting cervical artery dissection and unruptured aneurysms, raising the possibility that ultrastructural vessel wall abnormalities underlie the development of vascular lesions as well as RCVS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study we compared the frequency of neurovascular abnormalities in 158 consecutive RCVS patients, 44 patients with primary angiitis of the central nervous system (PACNS, positive controls), and 177 non-stroke patients with acute neurological symptoms (non-arteriopathy controls).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Coexisting neurovascular abnormalities were significantly higher ( p\u2009&lt;\u20090.001) in RCVS (23%) as compared to the PACNS (5%) or non-arteriopathy groups (8%). Cervical artery dissections were noted only in the RCVS group (8%, p\u2009&lt;\u20090.001). The RCVS group had more unruptured aneurysms than PACNS (13% vs. 5%, p\u2009=\u20090.099) or non-arteriopathy controls (13% vs. 7%, p\u2009=\u20090.05). Seven RCVS patients also had other vascular malformations (venous anomaly, cavernous malformations, fibromuscular dysplasia). There was no significant association between coexisting vascular abnormalities and brain lesions or discharge clinical outcome in the RCVS group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The high prevalence and heterogeneous anatomy of coexisting vascular lesions suggest that subtle ultrastructural arterial wall abnormalities may contribute to their development and also predispose to RCVS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102416637826","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T23:34:26Z","timestamp":1457393666000},"page":"29-35","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Coexisting vascular lesions in reversible cerebral vasoconstriction syndrome"],"prefix":"10.1177","volume":"37","author":[{"given":"M Akif","family":"Topcuoglu","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, USA"},{"name":"Department of Neurology, Hacettepe University Hospitals, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oguzhan","family":"Kursun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, USA"},{"name":"Neurology Clinics, Ankara Numune Education and Research Hospital, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneesh B","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"bibr1-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.68"},{"key":"bibr2-0333102416637826","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-1-200701020-00007"},{"key":"bibr3-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70135-7"},{"key":"bibr4-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm256"},{"key":"bibr5-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21951"},{"key":"bibr6-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc0809063"},{"key":"bibr7-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.3.411"},{"key":"bibr8-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a2cbe2"},{"key":"bibr9-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.510107"},{"key":"bibr10-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.1.96-a"},{"key":"bibr11-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.1.130"},{"key":"bibr12-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.639575"},{"key":"bibr13-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70081-3"},{"key":"bibr14-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822f03fc"},{"key":"bibr15-0333102416637826","first-page":"1247","volume":"2","author":"Day JW","year":"1986","journal-title":"Lancet"},{"key":"bibr16-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-011-0948-y"},{"key":"bibr17-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-013-1841-7"},{"key":"bibr18-0333102416637826","doi-asserted-by":"crossref","unstructured":"Kobayashi M. Diffuse cerebrovascular dilation: Case report of amezinium metilsulfate-induced reversible cerebral vasoconstriction syndrome.\n                      Cephalalgia\n                      . 2016; 36: 289\u2013293.","DOI":"10.1177\/0333102415588326"},{"key":"bibr19-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)24014-1"},{"key":"bibr20-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001740"},{"key":"bibr21-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414547139"},{"key":"bibr22-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.08.013"},{"key":"bibr23-0333102416637826","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000070"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102416637826","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102416637826","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102416637826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:47:20Z","timestamp":1777387640000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102416637826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1177\/0333102416637826"],"URL":"https:\/\/doi.org\/10.1177\/0333102416637826","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}