{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:10:11Z","timestamp":1779304211206,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Altered cerebrovascular tone is implicated in reversible cerebral vasoconstriction syndrome (RCVS). We evaluated vasomotor reactivity using bedside transcranial Doppler in RCVS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective case-control study, middle cerebral artery (MCA) blood flow velocities were compared at rest and in response to breath-hold in RCVS ( n\u2009=\u20098), Migraineurs ( n\u2009=\u200910), and non-headache Controls ( n\u2009=\u200910). Hyperventilation response was measured in RCVS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In RCVS, Breath Holding Index (BHI) was severely reduced in seven of eight patients and 14\/16 MCAs; seven of 16 MCAs showed exhausted (BHI\u2009&lt;\u20090.1) or inverted (BHI\u2009&lt;\u20090) vasomotor reactivity. Mean BHI in RCVS (0.23\u2009\u00b1\u20090.5) was significantly lower than Migraine (1.52\u2009\u00b1\u20090.57) and Controls (1.51\u2009\u00b1\u20090.32), p\u2009&lt;\u20090.001. Triphasic velocity responses were seen in all groups. The maximum V\n                      <jats:sub>mean<\/jats:sub>\n                      decline during the middle negative phase was \u221215.5\u2009\u00b1\u20099.2% in RCVS, \u221215.4\u2009\u00b1\u20097% in Migraine, and \u221210.3\u2009\u00b1\u20095% in Controls ( p\u2009=\u20090.04). In the late positive phase, average V\n                      <jats:sub>mean<\/jats:sub>\n                      increase was 6.2\u2009\u00b1\u200914% in RCVS, which was significantly lower ( p\u2009&lt;\u20090.001) than Migraine (30.5\u2009\u00b1\u200911%) and Controls (30.2\u2009\u00b1\u20096%). With hyperventilation, RCVS patients showed 23% decrease in V\n                      <jats:sub>mean<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cerebral arterial tone is abnormal in RCVS, with proximal vasoconstriction and abnormally reduced capacity for vasodilation. Further studies are needed to determine the utility of BHI to diagnose RCVS before angiographic reversibility is established, and to estimate prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102416650706","type":"journal-article","created":{"date-parts":[[2016,5,22]],"date-time":"2016-05-22T13:32:34Z","timestamp":1463923954000},"page":"541-547","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Cerebral vasomotor reactivity in reversible cerebral vasoconstriction syndrome"],"prefix":"10.1177","volume":"37","author":[{"given":"Mehmet Akif","family":"Topcuoglu","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Hacettepe University Hospitals, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk-tak","family":"Chan","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele Sampaio","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Neurology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric Edward","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth K","family":"Kwong","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneesh Bhim","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,5,20]]},"reference":[{"key":"bibr1-0333102416650706","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-1-200701020-00007"},{"key":"bibr2-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.68"},{"key":"bibr3-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm256"},{"key":"bibr4-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-82"},{"key":"bibr6-0333102416650706","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/ana.21951","volume":"67","author":"Chen SP","year":"2010","journal-title":"Ann Neurol"},{"key":"bibr7-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.1.130"},{"key":"bibr8-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc0809063"},{"key":"bibr9-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.572313"},{"key":"bibr10-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.3.411"},{"key":"bibr11-0333102416650706","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0929"},{"key":"bibr12-0333102416650706","first-page":"96","volume":"1","author":"Sharma VK","year":"2008","journal-title":"J Vasc Interv Neurol"},{"key":"bibr13-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.5.668"},{"key":"bibr14-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.07.057"},{"key":"bibr15-0333102416650706","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1468-2982.2003.00824.x","volume":"24","author":"Headache Classification Subcommittee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr16-0333102416650706","first-page":"9","volume-title":"Transcranial Doppler","author":"Fujioka KA","year":"1992"},{"key":"bibr17-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01285.x"},{"key":"bibr18-0333102416650706","first-page":"920","volume":"28","author":"Rosenbloom MH","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr19-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-8266(02)00045-9"},{"key":"bibr20-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.16.2122"},{"key":"bibr21-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2002.tb00129.x"},{"key":"bibr22-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.482810"},{"key":"bibr23-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000075605.36068.D9"},{"key":"bibr24-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21384"},{"key":"bibr25-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411410084"},{"key":"bibr26-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.08.023"},{"key":"bibr27-0333102416650706","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410394673"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102416650706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102416650706","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102416650706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:47:31Z","timestamp":1777387651000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/0333102416650706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,20]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1177\/0333102416650706"],"URL":"https:\/\/doi.org\/10.1177\/0333102416650706","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,20]]}}}