{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:23:49Z","timestamp":1777490629628,"version":"3.51.4"},"reference-count":78,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuroimaging studies revealed structural and functional changes in medication-overuse headache (MOH), but it remains unclear whether similar changes could be observed in other chronic pain disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, we investigated functional connectivity (FC) with resting-state functional magnetic resonance imaging (fMRI) and white matter integrity using diffusion tensor imaging (DTI) to measure fractional anisotropy (FA) and mean diffusivity (MD) in patients with MOH ( N\u2009=\u200912) relative to two control groups: patients with chronic myofascial pain (MYO; N\u2009=\u200911) and healthy controls (CN; N\u2009=\u200916).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In a data-driven approach we found hypoconnectivity in the fronto-parietal attention network in both pain groups relative to CN (i.e. MOH\u2009&lt;\u2009CN and MYO\u2009&lt;\u2009CN). In contrast, hyperconnectivity in the saliency network (SN) was detected only in MOH, which correlated with FA in the insula. In a seed-based analysis we investigated FC between the periaqueductal grey (PAG) and all other brain regions. In addition to overlapping hyperconnectivity seen in patient groups (relative to CN), MOH had a distinct connectivity pattern with lower FC to parieto-occipital regions and higher FC to orbitofrontal regions compared to controls. FA and MD abnormalities were mostly observed in MOH, involving the insula.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hyperconnectivity within the SN along with associated white matter changes therein suggest a particular role of this network in MOH. In addition, abnormal connectivity between the PAG and other pain modulatory (frontal) regions in MOH are consistent with dysfunctional central pain control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102416652625","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T00:06:21Z","timestamp":1464825981000},"page":"764-779","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Pain modulation is affected differently in medication-overuse headache and chronic myofascial pain \u2013 A multimodal MRI study"],"prefix":"10.1177","volume":"37","author":[{"given":"Lars","family":"Michels","sequence":"first","affiliation":[{"name":"Clinic of Neuroradiology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foteini","family":"Christidi","sequence":"additional","affiliation":[{"name":"Clinic of Neuroradiology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian R","family":"Steiger","sequence":"additional","affiliation":[{"name":"Division of Neuropsychology, Institute of Psychology, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S","family":"S\u00e1ndor","sequence":"additional","affiliation":[{"name":"RehaClinic, Bad Zurzach and Baden, Switzerland"},{"name":"University of Zurich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas R","family":"Gantenbein","sequence":"additional","affiliation":[{"name":"RehaClinic, Bad Zurzach and Baden, Switzerland"},{"name":"University of Zurich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunther","family":"Landmann","sequence":"additional","affiliation":[{"name":"Centre for Pain Medicine, Swiss Paraplegic-Centre, Nottwil, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian R","family":"Schreglmann","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spyros","family":"Kollias","sequence":"additional","affiliation":[{"name":"Clinic of Neuroradiology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Riederer","sequence":"additional","affiliation":[{"name":"University of Zurich, Z\u00fcrich, Switzerland"},{"name":"Neurological Center Rosenhuegel and Karl Landsteiner Institute for Epilepsy Research and Cognitive Neurology, Vienna, 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