{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:59:46Z","timestamp":1781751586596,"version":"3.54.5"},"reference-count":32,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cranial autonomic parasympathetic symptoms (CAPS) appear in at least half of migraine patients theoretically as a result of the release of peptides by the trigemino-vascular system (TVS). Cranial pain pathways become sensitised by repeated episodes of TVS activation, leading to migraine chronification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this article is to correlate the presence of CAPS with serum levels of vasoactive intestinal peptides (VIP) and calcitonin gene-related peptide (CGRP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Patients with chronic migraine (CM) were asked about the presence \u2013 during migraine attacks \u2013 of five CAPS, which were scored from 0 to 10 by using a quantitative scale. Serum VIP and CGRP levels were determined by ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We interviewed 87 CM patients (82 females; mean age 44.7\u2009\u00b1\u200910.6 years). Seventeen had no CAPS, while 70 reported at least one CAPS. VIP levels ranged from 20.8 to 668.2\u2009pg\/ml (mean 154.5\u2009\u00b1\u2009123.2). There was a significant positive correlation between scores in the CAPS scale and VIP levels (Spearman correlation coefficient\u2009=\u20090.227; p\u2009=\u20090.035). VIP levels were significantly higher in CM patients by at least one point in the scale vs those with 0 points ( p\u2009=\u20090.002). Analysing symptoms individually, VIP levels were numerically higher in those patients with symptoms, though they were significantly higher only in those patients with lacrimation vs those without it ( p\u2009=\u20090.013). There was no significant correlation between CGRP levels and the score in the CAPS scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum VIP, but not CGRP, levels seem to reflect the rate of activation of the parasympathetic arm of the TVS in migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102416653232","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T00:06:21Z","timestamp":1464825981000},"page":"823-827","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Relationship between serum levels of VIP, but not of CGRP, and cranial autonomic parasympathetic symptoms: A study in chronic migraine patients"],"prefix":"10.1177","volume":"37","author":[{"given":"N","family":"Riesco","sequence":"first","affiliation":[{"name":"Neuroscience Area, Service of Neurology, University Hospital Central de Asturias and INEUROPA, Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Cernuda-Moroll\u00f3n","sequence":"additional","affiliation":[{"name":"Neuroscience Area, Service of Neurology, University Hospital Central de Asturias and INEUROPA, Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Mart\u00ednez-Camblor","sequence":"additional","affiliation":[{"name":"Biostatistic Unit, University Hospital Central de Asturias Oviedo, Asturias, Spain"},{"name":"Universidad Aut\u00f3noma de Chile, Santiago de Chile, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AI","family":"P\u00e9rez-Alvarez","sequence":"additional","affiliation":[{"name":"Neuroscience Area, Service of Neurology, University Hospital Central de Asturias and INEUROPA, Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Verano","sequence":"additional","affiliation":[{"name":"Neuroscience Area, Service of Neurology, University Hospital Central de Asturias and INEUROPA, Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Garc\u00eda-Cabo","sequence":"additional","affiliation":[{"name":"Neuroscience Area, Service of Neurology, University Hospital Central de Asturias and INEUROPA, Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Serrano-Pertierra","sequence":"additional","affiliation":[{"name":"Neuroscience Area, Service of Neurology, University Hospital Central de Asturias and INEUROPA, Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pascual","sequence":"additional","affiliation":[{"name":"Neuroscience Area, Service of Neurology, University Hospital Central de Asturias and INEUROPA, Oviedo, Asturias, Spain"},{"name":"University Hospital Marqu\u00e9s de Valdecilla and IDIVAL, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,6,1]]},"reference":[{"key":"bibr1-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.127"},{"key":"bibr2-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010917"},{"key":"bibr3-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3057"},{"key":"bibr4-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280213"},{"key":"bibr5-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826170ce"},{"key":"bibr6-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00310.x"},{"key":"bibr7-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.09.007"},{"key":"bibr8-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1038\/384560a0"},{"key":"bibr10-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a6cb72"},{"key":"bibr11-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030505"},{"key":"bibr12-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000771"},{"key":"bibr13-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53491-0.00016-X"},{"key":"bibr14-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.162867"},{"key":"bibr15-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00358.x"},{"key":"bibr16-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg158"},{"key":"bibr17-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh236"},{"key":"bibr18-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01237.x"},{"key":"bibr19-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01316.x"},{"key":"bibr20-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.157743"},{"key":"bibr21-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-012-0164-4"},{"key":"bibr22-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829d872a"},{"key":"bibr23-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415593087"},{"key":"bibr24-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414535111"},{"key":"bibr25-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"bibr26-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.3.427"},{"key":"bibr27-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1111\/head.12372"},{"key":"bibr28-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000119"},{"key":"bibr29-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413512032"},{"key":"bibr30-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70209-1"},{"key":"bibr31-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70128-0"},{"key":"bibr32-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn307"},{"key":"bibr33-0333102416653232","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt369"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102416653232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102416653232","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102416653232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:47:34Z","timestamp":1777387654000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/0333102416653232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,1]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1177\/0333102416653232"],"URL":"https:\/\/doi.org\/10.1177\/0333102416653232","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,1]]}}}