{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:23:50Z","timestamp":1777490630686,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of our study is to assess the impact of triptan exposure on pregnancy outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a prospective observational cohort study with 432 pregnant women exposed to triptans and enrolled by the German Embryotox system. Pregnancy outcomes were compared with a migraine and a non-migraine comparison cohort. Primary objectives were major birth defects and spontaneous abortion; secondary endpoints were preterm delivery, birth weight, pregnancy complications and the rate of electively terminated pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to a non-migraine cohort the rates of major birth defects (OR\n                      <jats:sub>adj<\/jats:sub>\n                      0.84; 95% CI 0.4\u20131.9), spontaneous abortions (OR\n                      <jats:sub>adj<\/jats:sub>\n                      1.20; 95% CI 0.9\u20131.7), preterm delivery (OR\n                      <jats:sub>adj<\/jats:sub>\n                      1.01; 95% CI 0.7\u20131.5), and preeclampsia (OR\n                      <jats:sub>adj<\/jats:sub>\n                      1.33; 95% CI 0.7\u20132.5) were not increased in triptan-exposed pregnancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings support the evidence that triptans are not major teratogens. When compellingly needed during pregnancy, sumatriptan as the best studied triptan appears an acceptable treatment option. A detailed fetal ultrasound should be offered in cases of first trimester exposure to less well-studied triptans. Trial registration number in German Clinical Trials Register: DRKS00007660<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102417724152","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T07:42:10Z","timestamp":1501486930000},"page":"1081-1092","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Pregnancy outcome after anti-migraine triptan use: A prospective observational cohort study"],"prefix":"10.1177","volume":"38","author":[{"given":"Kevin","family":"Spielmann","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Pharmakovigilanzzentrum Embryonaltoxikologie, Institut f\u00fcr Klinische Pharmakologie und Toxikologie, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Kayser","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Pharmakovigilanzzentrum Embryonaltoxikologie, Institut f\u00fcr Klinische Pharmakologie und Toxikologie, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelin","family":"Beck","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Pharmakovigilanzzentrum Embryonaltoxikologie, Institut f\u00fcr Klinische Pharmakologie und Toxikologie, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Meister","sequence":"additional","affiliation":[{"name":"Beuth Hochschule f\u00fcr Technik Berlin (University of Applied Sciences), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Pharmakovigilanzzentrum Embryonaltoxikologie, Institut f\u00fcr Klinische Pharmakologie und Toxikologie, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"bibr1-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000252808.97649.21"},{"key":"bibr2-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01869.x"},{"key":"bibr3-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199912)60:6<356::AID-TERA8>3.0.CO;2-B"},{"key":"bibr4-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1111\/head.12500"},{"key":"bibr5-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100118943"},{"key":"bibr6-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1007\/s004040050252"},{"key":"bibr7-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1111\/head.12375"},{"key":"bibr8-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01619.x"},{"key":"bibr9-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9831-x"},{"key":"bibr10-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01529.x"},{"key":"bibr11-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.111006351.x"},{"key":"bibr12-0333102417724152","doi-asserted-by":"publisher","DOI":"10.2165\/11590370-000000000-00000"},{"key":"bibr13-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.2.581"},{"key":"bibr14-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2015.06.008"},{"key":"bibr15-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02172.x"},{"key":"bibr16-0333102417724152","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2000.00003.x"},{"key":"bibr17-0333102417724152","unstructured":"EUROCAT. 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