{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:04:45Z","timestamp":1792188285690,"version":"4.4.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is lack of evidence on how to detoxify medication-overuse headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the effect of complete stop of acute medication with restricted intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medication-overuse headache patients were included in a prospective, outpatient study and randomized to two months\u2019 detoxification with either a) no analgesics or acute migraine-medication (program A), or b) acute medication restricted to two days\/week (program B). Detoxification was followed by preventives if indicated. Patients were followed up at 2, 6 and 12 months. Percentage reduction in headache days\/month after 6 months was the primary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 72 medication-overuse headache patients with a primary migraine and\/or tension-type headache diagnosis. Fifty-nine completed detoxification, 58 (81%) were followed up at month 6 and 53 (74%) at month 12. At month 6, program A reduced headache days\/month by 46% (95% CI 34\u201358) compared with 22% (95% CI 11\u201334) in program-B ( p\u2009=\u20090.005), and 70% in program A versus 42% in program B were reverted to episodic headache ( p\u2009=\u20090.04). Migraine-days\/month were reduced by 7.2 in program A ( p\u2009&lt;\u20090.001) and 3.6 in program B ( p\u2009=\u20090.002) after 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both detoxification programs were very effective. Detoxification without analgesics or acute migraine-medication was the most effective program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Clinicaltrials.gov (NCT02903329).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102417737779","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T22:59:54Z","timestamp":1508453994000},"page":"225-236","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":98,"title":["Complete detoxification is the most effective treatment of medication-overuse headache: A randomized controlled open-label trial"],"prefix":"10.1177","volume":"38","author":[{"given":"Louise Ninett","family":"Carlsen","sequence":"first","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe Bruun","family":"Munksgaard","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rigmor H\u00f8jland","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"bibr1-0333102417737779","doi-asserted-by":"crossref","unstructured":"Vos T, Barber RM, Bell B, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990\u20132013: A systematic analysis for the Global Burden of Disease Study 2013.\n                      Lancet\n                      2015; 386: 743\u2013800.","DOI":"10.1016\/S0140-6736(15)60692-4"},{"key":"bibr2-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03497.x"},{"key":"bibr3-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412451363"},{"key":"bibr4-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414521508"},{"key":"bibr5-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01712.x"},{"key":"bibr6-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01631.x"},{"key":"bibr7-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/head.12487"},{"key":"bibr8-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12517"},{"key":"bibr9-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-10"},{"key":"bibr10-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412462638"},{"key":"bibr11-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0402-9"},{"key":"bibr12-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01190.x"},{"key":"bibr13-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02191.x"},{"key":"bibr14-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"bibr15-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00980.x"},{"key":"bibr16-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01711.x"},{"key":"bibr17-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01198.x"},{"key":"bibr18-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000217914.30994.bd"},{"key":"bibr19-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413515338"},{"key":"bibr20-0333102417737779","first-page":"1\u201312","volume":"17","author":"Find NL","year":"2015","journal-title":"J Headache Pain"},{"key":"bibr21-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0561-1"},{"key":"bibr22-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416660549"},{"key":"bibr23-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00789.x"},{"key":"bibr24-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/head.12125"},{"key":"bibr25-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/head.12128"},{"key":"bibr26-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412475235"},{"key":"bibr27-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411425867"},{"key":"bibr28-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.05.003"},{"key":"bibr29-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00684.x"},{"key":"bibr30-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30083-2"},{"key":"bibr31-0333102417737779","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416678382"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102417737779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102417737779","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102417737779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:47:42Z","timestamp":1777387662000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102417737779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,19]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1177\/0333102417737779"],"URL":"https:\/\/doi.org\/10.1177\/0333102417737779","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,19]]}}}