{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:24:36Z","timestamp":1777490676939,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It has been proposed that multiple sclerosis lesions afflicting the pontine trigeminal afferents contribute to trigeminal neuralgia in multiple sclerosis. So far, there are no imaging studies that have evaluated interactions between supratentorial lesions and trigeminal neuralgia in multiple sclerosis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study and sought multiple sclerosis patients with trigeminal neuralgia and controls in a local database. Multiple sclerosis lesions were manually outlined and transformed into stereotaxic space. We determined the lesion overlap and performed a voxel-wise subtraction analysis. Secondly, we conducted a voxel-wise non-parametric analysis using the Liebermeister test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 12,210 multiple sclerosis patient records screened, we identified 41 patients with trigeminal neuralgia. The voxel-wise subtraction analysis yielded associations between trigeminal neuralgia and multiple sclerosis lesions in the pontine trigeminal afferents, as well as larger supratentorial lesion clusters in the contralateral insula and hippocampus. The non-parametric statistical analysis using the Liebermeister test yielded similar areas to be associated with multiple sclerosis-related trigeminal neuralgia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study confirms previous data on associations between multiple sclerosis-related trigeminal neuralgia and pontine lesions, and showed for the first time an association with lesions in the insular region, a region involved in pain processing and endogenous pain modulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102417737788","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T23:07:21Z","timestamp":1508281641000},"page":"1326-1334","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Supratentorial lesions contribute to trigeminal neuralgia in multiple sclerosis"],"prefix":"10.1177","volume":"38","author":[{"given":"Kilian","family":"Fr\u00f6hlich","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klemens","family":"Winder","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf A","family":"Linker","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Engelhorn","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnd","family":"D\u00f6rfler","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max J","family":"Hilz","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Germany"},{"name":"Autonomic Unit, University College London, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schwab","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"bibr1-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000128"},{"key":"bibr2-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515579440"},{"key":"bibr3-0333102417737788","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders, 3rd edition (beta version).\n                      Cephalalgia\n                      2013; 33: 629\u2013808.","DOI":"10.1177\/0333102413485658"},{"key":"bibr4-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23578"},{"key":"bibr5-0333102417737788","first-page":"1165","volume":"27","author":"Ge Y","year":"2006","journal-title":"Am J Neuroradiol"},{"key":"bibr6-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.12.026"},{"key":"bibr7-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.4.1142"},{"key":"bibr8-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.1.101"},{"key":"bibr9-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002720"},{"key":"bibr10-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/65228893"},{"key":"bibr11-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.12.2347"},{"key":"bibr12-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1038\/nn1050"},{"key":"bibr13-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2007.19.7.1081"},{"key":"bibr14-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24746"},{"key":"bibr15-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7907-0"},{"key":"bibr16-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx080"},{"key":"bibr17-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"bibr18-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"bibr19-0333102417737788","unstructured":"McCausland Center for Brain Imaging. MRIcron software, http:\/\/www.mccauslandcenter.sc.edu\/mricro\/mricron (2007, accessed 04 June 2016)."},{"key":"bibr20-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.020"},{"key":"bibr21-0333102417737788","unstructured":"Wellcome Department of Cognitive Neuroscience, University College London. Statistical Parametric Mapping (SPM), http:\/\/www.fil.ion.ucl.ac.uk (2012, accessed 04 June 2017)."},{"key":"bibr22-0333102417737788","unstructured":"McCausland Center for Brain Imaging. Clinical Toolbox for SPM8, http:\/\/www.nitrc.org\/frs\/?group_id=881 (2012, accessed 04 June 2017)."},{"key":"bibr23-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws153"},{"key":"bibr24-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv333"},{"key":"bibr25-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"bibr26-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1046\/j.0305-1846.2001.00318.x"},{"key":"bibr27-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1038\/72131"},{"key":"bibr28-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr265"},{"key":"bibr29-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2555"},{"key":"bibr30-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000207"},{"key":"bibr31-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1038\/nn1176"},{"key":"bibr32-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf137"},{"key":"bibr33-0333102417737788","doi-asserted-by":"crossref","unstructured":"Lorenz R, Gleich T, Kuehn S, et\u00a0al. Subjective illusion of control modulates striatal reward anticipation in adolescence.\n                      Neuroimage\n                      2015; 117: 250\u2013257.","DOI":"10.1016\/j.neuroimage.2015.05.024"},{"key":"bibr34-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90068-3"},{"key":"bibr35-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23117"},{"key":"bibr36-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000171862.17301.84"},{"key":"bibr37-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn346"},{"key":"bibr38-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906186106"},{"key":"bibr39-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1038\/srep36030"},{"key":"bibr40-0333102417737788","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.8.1469"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102417737788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102417737788","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102417737788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:47:43Z","timestamp":1777387663000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102417737788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,17]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1177\/0333102417737788"],"URL":"https:\/\/doi.org\/10.1177\/0333102417737788","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,17]]}}}