{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:40:29Z","timestamp":1790484029761,"version":"4.1.0"},"reference-count":248,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To review and discuss the literature relevant to the role of brainstem structure and function in headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary headache disorders, such as migraine and cluster headache, are considered disorders of the brain. As well as head-related pain, these headache disorders are also associated with other neurological symptoms, such as those related to sensory, homeostatic, autonomic, cognitive and affective processing that can all occur before, during or even after headache has ceased. Many imaging studies demonstrate activation in brainstem areas that appear specifically associated with headache disorders, especially migraine, which may be related to the mechanisms of many of these symptoms. This is further supported by preclinical studies, which demonstrate that modulation of specific brainstem nuclei alters sensory processing relevant to these symptoms, including headache, cranial autonomic responses and homeostatic mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review focus<\/jats:title>\n                    <jats:p>This review will specifically focus on the role of brainstem structures relevant to primary headaches, including medullary, pontine, and midbrain, and describe their functional role and how they relate to mechanisms of primary headaches, especially migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102418784698","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T11:43:26Z","timestamp":1530618206000},"page":"1635-1660","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Brain structure and function related to headache: Brainstem structure and function in headache"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0652-2988","authenticated-orcid":false,"given":"Marta","family":"Vila-Pueyo","sequence":"first","affiliation":[{"name":"Headache Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2103-9081","authenticated-orcid":false,"given":"Jan","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Romero-Reyes","sequence":"additional","affiliation":[{"name":"Department of Neural and Pain Sciences, University of Maryland Baltimore, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Akerman","sequence":"additional","affiliation":[{"name":"Department of Neural and Pain Sciences, University of Maryland Baltimore, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,7,3]]},"reference":[{"key":"bibr1-0333102418784698","volume-title":"Principles of neural science","author":"Kandel ER","year":"2000","edition":"4"},{"key":"bibr2-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3057"},{"key":"bibr3-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67217-0"},{"key":"bibr4-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.07.021"},{"key":"bibr5-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/head.12471"},{"key":"bibr6-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"bibr7-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90596-0"},{"key":"bibr8-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-12-02545.1983"},{"key":"bibr9-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/306684a0"},{"key":"bibr10-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00249.2005"},{"key":"bibr11-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1431"},{"key":"bibr12-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2000.11746137"},{"key":"bibr13-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2001.11746164"},{"key":"bibr14-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2001.11746145"},{"key":"bibr15-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2001.11746155"},{"key":"bibr16-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1940.02280070051003"},{"key":"bibr17-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1940.01210040002001"},{"key":"bibr18-0333102418784698","first-page":"279","volume-title":"Physiological aspects of clinical neurology","author":"McNaughton FL","year":"1977"},{"key":"bibr19-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902030414"},{"key":"bibr20-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374236-0.10031-8"},{"key":"bibr21-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90486-7"},{"key":"bibr22-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1997.19030367.x"},{"key":"bibr23-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1999.19440579.x"},{"key":"bibr24-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.2.964"},{"key":"bibr25-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf166"},{"key":"bibr26-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg190"},{"key":"bibr27-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00009-6"},{"key":"bibr28-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01478.x"},{"key":"bibr29-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.02.078"},{"key":"bibr30-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.07.045"},{"key":"bibr31-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05168.x"},{"key":"bibr32-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1981.45.2.173"},{"key":"bibr33-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00048-3"},{"key":"bibr34-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00009-6"},{"key":"bibr35-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-5013.2005.20201.x"},{"key":"bibr36-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"bibr37-0333102418784698","first-page":"14","volume":"27","author":"Fernandes G","year":"2013","journal-title":"J Orofac Pain"},{"key":"bibr38-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b389c2"},{"key":"bibr39-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31820e12f5"},{"key":"bibr40-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01511.x"},{"key":"bibr41-0333102418784698","first-page":"287","volume":"24","author":"Franco AL","year":"2010","journal-title":"J Orofac Pain"},{"key":"bibr42-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.14.030191.001251"},{"key":"bibr43-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1985.0037"},{"key":"bibr44-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2002.0224"},{"key":"bibr45-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20751"},{"key":"bibr46-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2010.12.002"},{"key":"bibr47-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902110304"},{"key":"bibr48-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.24"},{"key":"bibr49-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.6_suppl_4.S3"},{"key":"bibr50-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199902000-00001"},{"key":"bibr51-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90125-U"},{"key":"bibr52-0333102418784698","doi-asserted-by":"crossref","unstructured":"Gray H.\n                      Anatomy of the human body\n                      . Philadelphia: Lea & Febiger, 1918 (www.bartleby.com\/107\/).","DOI":"10.5962\/bhl.title.20311"},{"key":"bibr53-0333102418784698","first-page":"R517","volume":"257","author":"Goadsby PJ","year":"1989","journal-title":"Am J Physiol"},{"key":"bibr54-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91211-X"},{"key":"bibr55-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.72.2.470"},{"key":"bibr56-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01501.x"},{"key":"bibr57-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws249"},{"key":"bibr58-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.157743"},{"key":"bibr59-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt369"},{"key":"bibr60-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01497.x"},{"key":"bibr61-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn307"},{"key":"bibr62-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.3.427"},{"key":"bibr63-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280213"},{"key":"bibr64-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0660-7"},{"key":"bibr65-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.113"},{"key":"bibr66-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1988.117"},{"key":"bibr67-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0373-15.2015"},{"key":"bibr68-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01501.x"},{"key":"bibr69-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90664-9"},{"key":"bibr70-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228793"},{"key":"bibr71-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0439-13.2013"},{"key":"bibr72-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20688"},{"key":"bibr73-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1007\/BF02147990"},{"key":"bibr74-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.061604.135709"},{"key":"bibr75-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(03)00143-7"},{"key":"bibr76-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23024"},{"key":"bibr77-0333102418784698","doi-asserted-by":"publisher","DOI":"10.2174\/157015908785777193"},{"key":"bibr78-0333102418784698","doi-asserted-by":"publisher","DOI":"10.2174\/157015908785777229"},{"key":"bibr79-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.06.009"},{"key":"bibr80-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c2937c"},{"key":"bibr81-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.12.003"},{"key":"bibr82-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.01.002"},{"key":"bibr83-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414541687"},{"key":"bibr84-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01303.x"},{"key":"bibr85-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002789"},{"key":"bibr86-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000052998.58526.A9"},{"key":"bibr87-0333102418784698","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1526-4610.2007.00779.x","volume":"48","author":"Alstadhaug K","year":"2008","journal-title":"Headache"},{"key":"bibr88-0333102418784698","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.59.3.326"},{"key":"bibr89-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095508"},{"key":"bibr90-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww097"},{"key":"bibr91-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh416"},{"key":"bibr92-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2001.00285.x"},{"key":"bibr93-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00348-T"},{"issue":"1","key":"bibr94-0333102418784698","first-page":"152","volume":"36","author":"Vila-Pueyo M","year":"2016","journal-title":"Cephalalgia"},{"key":"bibr95-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91537-0"},{"key":"bibr96-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90058-0"},{"key":"bibr97-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90236-6"},{"key":"bibr98-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.104166"},{"key":"bibr99-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301570"},{"key":"bibr100-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000437"},{"key":"bibr101-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.09.039"},{"key":"bibr102-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-7-94"},{"key":"bibr103-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2001.00140.x"},{"key":"bibr104-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0891-0618(91)90020-D"},{"key":"bibr105-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902700206"},{"key":"bibr106-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90260-X"},{"key":"bibr107-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02600.x"},{"key":"bibr108-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00076-6"},{"issue":"1","key":"bibr109-0333102418784698","first-page":"152","volume":"36","author":"Vila-Pueyo M","year":"2016","journal-title":"Cephalalgia"},{"key":"bibr110-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.11.069"},{"key":"bibr111-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.12.010"},{"key":"bibr112-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20369"},{"key":"bibr113-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2003.10.002"},{"key":"bibr114-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-7339(10)70071-0"},{"key":"bibr115-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90442-1"},{"key":"bibr116-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(92)90246-T"},{"key":"bibr117-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(97)00019-7"},{"key":"bibr118-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890020403"},{"key":"bibr119-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90136-4"},{"key":"bibr120-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90637-M"},{"key":"bibr121-0333102418784698","volume-title":"Neuropeptide in the CNS, part II","author":"Bj\u00f6rklund AHT","year":"1990"},{"key":"bibr122-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199701000-00002"},{"key":"bibr123-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(75)90098-6"},{"key":"bibr124-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.10.004"},{"key":"bibr125-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00405-X"},{"key":"bibr126-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01572.x"},{"key":"bibr127-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1292-1"},{"key":"bibr128-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-S1-P67"},{"key":"bibr129-0333102418784698","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/0333102412468681","volume":"33","author":"Supronsinchai W","year":"2013","journal-title":"Cephalalgia"},{"key":"bibr130-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.2.584"},{"key":"bibr131-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-05-01933.2003"},{"key":"bibr132-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00750.2004"},{"key":"bibr133-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3536-04.2005"},{"key":"bibr134-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506226102"},{"key":"bibr135-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0173-13.2013"},{"key":"bibr136-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22559"},{"key":"bibr137-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05327-8"},{"key":"bibr138-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.11.006"},{"key":"bibr139-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.73.2.568"},{"key":"bibr140-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2001.00285.x"},{"key":"bibr141-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000688"},{"key":"bibr142-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01588.x"},{"key":"bibr143-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411398152"},{"key":"bibr144-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01829.x"},{"key":"bibr145-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.03.024"},{"key":"bibr146-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1113\/eph8702357"},{"key":"bibr147-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902950408"},{"key":"bibr148-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-006-0587-x"},{"key":"bibr149-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902900404"},{"key":"bibr150-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903080212"},{"key":"bibr151-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.06.022"},{"key":"bibr152-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(87)90102-1"},{"key":"bibr153-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.05.067"},{"key":"bibr154-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01806-5"},{"key":"bibr155-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199308000-00008"},{"key":"bibr156-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13662"},{"key":"bibr157-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1177\/1744806917709201"},{"key":"bibr158-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8713-x"},{"key":"bibr159-0333102418784698","doi-asserted-by":"crossref","unstructured":"Lowry CA, Evans AK, Gasser PJ, et\u00a0al. Topographic organization and chemoarchitecture of the dorsal raphe nucleus and the median raphe nucleus. In: Monti JM, Pandi-Perumal SR, Jacobs BL, et al. (eds)\n                      Serotonin and sleep: Molecular, Functional and Clinical Aspect\n                      . Basel, Switzerland: Birkshauser Verlag AG, pp.25\u201367.","DOI":"10.1007\/978-3-7643-8561-3_2"},{"key":"bibr160-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.11.004"},{"key":"bibr161-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902430307"},{"key":"bibr162-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902030410"},{"key":"bibr163-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91437-W"},{"key":"bibr164-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1033"},{"key":"bibr165-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90239-8"},{"key":"bibr166-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07936.x"},{"key":"bibr167-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90043-N"},{"key":"bibr168-0333102418784698","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00105"},{"key":"bibr169-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903320402"},{"key":"bibr170-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903500103"},{"key":"bibr171-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90143-0"},{"key":"bibr172-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90157-4"},{"key":"bibr173-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90480-7"},{"key":"bibr174-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00103-8"},{"key":"bibr175-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.91"},{"key":"bibr176-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1989.0902107.x"},{"key":"bibr177-0333102418784698","first-page":"R257","volume":"248","author":"Goadsby PJ","year":"1985","journal-title":"Am J Physiol"},{"key":"bibr178-0333102418784698","first-page":"R263","volume":"248","author":"Goadsby PJ","year":"1985","journal-title":"Am J Physiol"},{"key":"bibr179-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23209"},{"key":"bibr180-0333102418784698","unstructured":"Amoozegar F. Depression comorbidity in migraine.\n                      Int Rev Psychiatry\n                      2017: 1\u201312."},{"key":"bibr181-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.01.002"},{"key":"bibr182-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291701004822"},{"key":"bibr183-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.01.083"},{"key":"bibr184-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1410.004"},{"key":"bibr185-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/nm0795-658"},{"key":"bibr186-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417698708"},{"key":"bibr187-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290116"},{"key":"bibr188-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705258"},{"key":"bibr189-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00647.x"},{"key":"bibr190-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1126\/science.164.3878.444"},{"key":"bibr191-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(84)90015-0"},{"key":"bibr192-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860315)57:6<1266::AID-CNCR2820570634>3.0.CO;2-Q"},{"key":"bibr193-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1987.hed2708416.x"},{"key":"bibr194-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00303-7"},{"key":"bibr195-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)01250-8"},{"key":"bibr196-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20193"},{"key":"bibr197-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.14.030191.001251"},{"key":"bibr198-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1431"},{"key":"bibr199-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1985.0037"},{"key":"bibr200-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000344"},{"key":"bibr201-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02140.x"},{"key":"bibr202-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.12.020"},{"key":"bibr203-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.085"},{"key":"bibr204-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415576723"},{"key":"bibr205-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.02.005"},{"key":"bibr206-0333102418784698","unstructured":"Holland PR, Akerman S, Lasalandra MP, et\u00a0al. Antinociceptive effects of orexin A in the vlPAG are blocked by 5-HT1B\/1D receptor antagonism.\n                      Headache\n                      2008; 48: S6."},{"key":"bibr207-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.10.022"},{"key":"bibr208-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00171-7"},{"key":"bibr209-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.090951"},{"key":"bibr210-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00842.x"},{"key":"bibr211-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998"},{"key":"bibr212-0333102418784698","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1526-4610.2007.00966.x","volume":"48","author":"Akerman S","year":"2008","journal-title":"Headache"},{"key":"bibr213-0333102418784698","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200060060-00003"},{"key":"bibr214-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6749"},{"key":"bibr215-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306147101"},{"key":"bibr216-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10785"},{"key":"bibr217-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13643.x"},{"key":"bibr218-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701456"},{"key":"bibr219-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)83024-5"},{"key":"bibr220-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1703153.x"},{"key":"bibr221-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.5.1419"},{"key":"bibr222-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183717"},{"key":"bibr223-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13341"},{"key":"bibr224-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx089"},{"key":"bibr225-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.1.249"},{"key":"bibr226-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww096"},{"key":"bibr227-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000175250.33159.a9"},{"key":"bibr228-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20778"},{"key":"bibr229-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.10.014"},{"key":"bibr230-0333102418784698","doi-asserted-by":"crossref","unstructured":"Akerman S and Romero-Reyes M. Targeting the central projection of the dural trigeminovascular system for migraine prophylaxis.\n                      J Cereb Blood Flow Metab\n                      2017: 271678X17729280.","DOI":"10.1177\/0271678X17729280"},{"key":"bibr231-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411418259"},{"key":"bibr232-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00767.x"},{"key":"bibr233-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70047-9"},{"key":"bibr234-0333102418784698","doi-asserted-by":"crossref","unstructured":"Vila-Pueyo M. Targeted 5-HT1F therapies for migraine.\n                      Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics\n                      2018; 15: 291\u2013303.","DOI":"10.1007\/s13311-018-0615-6"},{"key":"bibr235-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030505"},{"key":"bibr236-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705807"},{"key":"bibr237-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0869-05.2005"},{"key":"bibr238-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01745.x"},{"key":"bibr239-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410363491"},{"key":"bibr240-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70209-1"},{"key":"bibr241-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70128-0"},{"key":"bibr242-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00249-5"},{"key":"bibr243-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00019-3"},{"key":"bibr244-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01195.x"},{"key":"bibr245-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412472071"},{"key":"bibr246-0333102418784698","volume-title":"Neuroanatomy for medical students","author":"Wilkinson J","year":"1998","edition":"3"},{"key":"bibr247-0333102418784698","volume-title":"The mouse brain in stereotaxic coordinates","author":"Paxinos G","year":"2003","edition":"2"},{"key":"bibr248-0333102418784698","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374236-0.10010-0"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102418784698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102418784698","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102418784698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:47:59Z","timestamp":1777387679000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102418784698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,3]]},"references-count":248,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1177\/0333102418784698"],"URL":"https:\/\/doi.org\/10.1177\/0333102418784698","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,3]]}}}