{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:03:17Z","timestamp":1790143397751,"version":"4.0.1"},"reference-count":45,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several previous studies have investigated cortical abnormalities, specifically cortical thickness, in patients with migraine, with variable results. The relatively small sample sizes of most previous studies may partially explain these inconsistencies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate differences of cortical thickness between control subjects and migraineurs in a large cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three Tesla MRI data of 131 patients (38 with and 93 without aura) and 115 control subjects were analysed. A vertex-wise linear model was applied controlling for age, gender and MRI scanner to investigate differences between groups and determine the impact of clinical factors on cortical thickness measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Migraineurs showed areas of thinned cortex compared with controls bilaterally in the central sulcus, in the left middle-frontal gyrus, in left visual cortices and the right occipito-temporal gyrus. Frequency of migraine attacks and the duration of the disorder had a significant impact on cortical thickness in the sensorimotor cortex and middle-frontal gyrus. Patients without aura showed thinner cortex than controls bilaterally in the central sulcus and in the middle frontal gyrus, in the left primary visual cortices, in the left supramarginal gyrus and in the right cuneus. Patients with aura showed clusters of thinner cortex bilaterally in the subparietal sulcus (between the precuneus and posterior cingulate cortex), in the left intraparietal sulcus and in the right anterior cingulate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results indicate cortical abnormalities in specific brain regions in migraineurs. Some of the observed abnormalities may reflect a genetic susceptibility towards developing migraine attacks, while others are probably a consequence of repeated head pain attacks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102418795163","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T21:16:02Z","timestamp":1544476562000},"page":"665-673","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":73,"title":["Cortical abnormalities in episodic migraine: A multi-center 3T MRI study"],"prefix":"10.1177","volume":"39","author":[{"given":"Stefano","family":"Magon","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland"},{"name":"Medical Image Analysis Center, University Hospital Basel, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"May","sequence":"additional","affiliation":[{"name":"Institute for Systems Neuroscience, University of Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Stankewitz","sequence":"additional","affiliation":[{"name":"Institute for Systems Neuroscience, University of Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, Technische Universit\u00e4t Muenchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3260-5904","authenticated-orcid":false,"given":"Peter J","family":"Goadsby","sequence":"additional","affiliation":[{"name":"Headache Group-Department of Neurology, University of California, San Francisco, CA, USA"},{"name":"NIHR-Wellcome Trust King\u2019s Clinical Research Facility, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schankin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[{"name":"Danish Headache Center and Department of Neurology, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal M","family":"Amin","sequence":"additional","affiliation":[{"name":"Danish Headache Center and Department of Neurology, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian L","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Neurology, Technische Universit\u00e4t Muenchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mallar Chakravarty","sequence":"additional","affiliation":[{"name":"Cerebral Imaging Centre, Douglas Mental Health University Institute Montreal, Montreal, Quebec, Canada"},{"name":"Department of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannis","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Sprenger","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland"},{"name":"Department of Neurology, DKD HELIOS Klinik Wiesbaden, Wiesbaden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"bibr1-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000086"},{"key":"bibr2-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000291618.32247.2d"},{"key":"bibr3-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414531155"},{"key":"bibr4-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030402"},{"key":"bibr5-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122004"},{"key":"bibr6-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414532378"},{"key":"bibr7-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.02.007"},{"key":"bibr8-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411421025"},{"key":"bibr9-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000159"},{"key":"bibr10-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412445622"},{"key":"bibr11-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7201-y"},{"key":"bibr12-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414531157"},{"key":"bibr13-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2154-15.2015"},{"key":"bibr14-0333102418795163","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1111\/j.1468-2982.2003.00824.x","volume":"24","author":"Headache Classification Subcommittee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr15-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200033797"},{"key":"bibr16-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.051"},{"key":"bibr17-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.03.051"},{"key":"bibr18-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"bibr19-0333102418795163","volume-title":"Human brain: Surface, three dimensional sectional anatomy and MRI","author":"Duvernoy H","year":"1991"},{"key":"bibr20-0333102418795163","doi-asserted-by":"publisher","DOI":"10.2307\/2347973"},{"key":"bibr21-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1974.10482955"},{"key":"bibr22-0333102418795163","first-page":"713","volume":"6","author":"Gabriel QC","year":"2013","journal-title":"J Pain Res"},{"key":"bibr23-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-424X(09)70341-1"},{"key":"bibr24-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5538-08.2009"},{"key":"bibr25-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2008.05.005"},{"key":"bibr26-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063414"},{"key":"bibr27-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2011.21619"},{"key":"bibr28-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-17"},{"key":"bibr29-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22062"},{"key":"bibr30-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx382"},{"key":"bibr31-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415606080"},{"key":"bibr32-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.11.2189"},{"key":"bibr33-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1010-12.2012"},{"key":"bibr34-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn036"},{"key":"bibr35-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22537"},{"key":"bibr36-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01183.x"},{"key":"bibr37-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"bibr38-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052927"},{"key":"bibr39-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.04.002"},{"key":"bibr40-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01428.x"},{"key":"bibr41-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3516"},{"key":"bibr42-0333102418795163","first-page":"4311","volume":"8","author":"Hu W","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"bibr43-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02217.x"},{"key":"bibr44-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm165"},{"key":"bibr45-0333102418795163","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12296"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102418795163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102418795163","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102418795163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:48:03Z","timestamp":1777387683000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102418795163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,10]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1177\/0333102418795163"],"URL":"https:\/\/doi.org\/10.1177\/0333102418795163","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,10]]}}}