{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:28:04Z","timestamp":1780518484623,"version":"3.54.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ministry of Education, Taiwan"},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V106C-106, V105C-127"],"award-info":[{"award-number":["V106C-106, V105C-127"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100015811","name":"Brain Research Center, National Yang-Ming University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015811","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"crossref","award":["MOST 106-2314-B-075 -021"],"award-info":[{"award-number":["MOST 106-2314-B-075 -021"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"crossref","award":["MOST 106-2321-B-010-009"],"award-info":[{"award-number":["MOST 106-2321-B-010-009"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Several brain and spinal magnetic resonance imaging signs have been described in spontaneous intracranial hypotension. Their correlations are not fully studied. This study aimed to explore potential mechanisms underlying cerebral neuroimaging findings and to examine associations among spinal and brain magnetic resonance imaging signs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review of magnetic resonance myelography and brain magnetic resonance imaging records of patients with spontaneous intracranial hypotension. Categorical principal component analysis was employed to cluster brain neuroimaging findings. Spearman correlation was employed to analyze associations among different brain neuroimaging findings and between brain and spinal neuroimaging findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In patients with spontaneous intracranial hypotension (n\u2009=\u2009148), categorical principal component analysis of brain neuroimaging signs revealed two clusters: Cerebral venous dilation and brain descent. Among all brain magnetic resonance imaging signs examined, only midbrain-pons angle associated with anterior epidural cerebrospinal fluid collection length (surrogate spinal cerebrospinal fluid leak severity) (n\u2009=\u2009148, Spearman\u2019s \u03c1\u2009=\u2009\u22120.38, p\u2009&lt;\u2009.001). Subgroup analyses showed that the association between midbrain-pons angle (within brain descent cluster) and spinal cerebrospinal fluid leak severity was presented in patients with convex margins of the transverse sinuses (n\u2009=\u2009122, Spearman\u2019s \u03c1\u2009=\u2009\u22120.43, p\u2009&lt;\u2009.001), but not in patients without convex margins (n\u2009=\u200926, Spearman\u2019s \u03c1\u2009=\u2009\u22120.19, p\u2009=\u2009.348). The association between severity of transverse sinus distension and spinal cerebrospinal fluid leak severity was only presented in patients without convex margins (n\u2009=\u200926, Spearman\u2019s \u03c1\u2009=\u20090.52, p\u2009=\u2009.006).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study indicates that there are two factors behind the brain neuroimaging findings in spontaneous intracranial hypotension: Cerebral venous dilation and brain descent. Certain brain neuroimaging signs correlate with spinal cerebrospinal fluid leakage severity, depending on different circumstances.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102418804161","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:40:02Z","timestamp":1539132002000},"page":"1998-2005","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Correlations among brain and spinal MRI findings in spontaneous intracranial hypotension"],"prefix":"10.1177","volume":"38","author":[{"given":"Jr-Wei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurology, Taipei City Hospital, Taipei City, Taiwan"},{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei City, Taiwan"},{"name":"Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Ling","family":"Fuh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei City, Taiwan"},{"name":"Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiing-Feng","family":"Lirng","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei City, Taiwan"},{"name":"Department of Radiology, Taipei Veterans General Hospital, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-9902","authenticated-orcid":false,"given":"Shih-Pin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei City, Taiwan"},{"name":"Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei City, Taiwan"},{"name":"Institute of Clinical Medicine, National Yang-Ming University, Taipei City, Taiwan"},{"name":"Division of Translational Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Shya","family":"Hseu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei City, Taiwan"},{"name":"Department of Anaesthesiology, Taipei Veterans General Hospital, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuu-Jiun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei City, Taiwan"},{"name":"Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei City, Taiwan"},{"name":"Brain Research Center, National Yang-Ming University, Taipei City, Taiwan"},{"name":"Institute of Brain Science, National Yang-Ming University, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"bibr1-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.19.2286"},{"key":"bibr2-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1111\/head.12149"},{"key":"bibr3-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00015-0"},{"key":"bibr4-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.5.919"},{"key":"bibr5-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww328"},{"key":"bibr6-0333102418804161","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4689"},{"key":"bibr7-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.12.1746"},{"key":"bibr8-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01498.x"},{"key":"bibr9-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000120750.40453.64"},{"key":"bibr10-0333102418804161","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0621"},{"key":"bibr11-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002896"},{"key":"bibr12-0333102418804161","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.8611"},{"key":"bibr13-0333102418804161","unstructured":"Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition.\n                      Cephalalgia\n                      2004; 24: 9\u2013160."},{"key":"bibr14-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1080\/j.1600-0455.2002.430304.x"},{"key":"bibr15-0333102418804161","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.4.0608"},{"key":"bibr16-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01249.x"},{"key":"bibr17-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330205"},{"key":"bibr18-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm101"},{"key":"bibr19-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c3fd99"},{"key":"bibr20-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv016"},{"key":"bibr21-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002986"},{"key":"bibr22-0333102418804161","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1277"},{"key":"bibr23-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01376.x"},{"key":"bibr24-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.12.3.336"},{"key":"bibr25-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-018-3263-z"},{"key":"bibr26-0333102418804161","doi-asserted-by":"crossref","unstructured":"Kranz PG, Gray L and Amrhein TJ. Spontaneous intracranial hypotension: 10 myths and misperceptions.\n                      Headache\n                      2018; 58: 948\u2013959.","DOI":"10.1111\/head.13328"},{"key":"bibr27-0333102418804161","doi-asserted-by":"publisher","DOI":"10.1007\/BF02345321"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102418804161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102418804161","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102418804161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:48:05Z","timestamp":1777387685000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102418804161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":27,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1177\/0333102418804161"],"URL":"https:\/\/doi.org\/10.1177\/0333102418804161","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,9]]}}}