{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:11:29Z","timestamp":1780373489786,"version":"3.54.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107-2321-B-010-001"],"award-info":[{"award-number":["MOST 107-2321-B-010-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V108C-105"],"award-info":[{"award-number":["V108C-105"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW 108-TDU-B-211-133001"],"award-info":[{"award-number":["MOHW 108-TDU-B-211-133001"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005382","name":"National Yang-Ming University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine is associated with syncope. We investigated risk factors for syncope and burden of syncope in migraine patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were recruited from a headache clinic. All participants provided information on lifestyle, co-morbidity, syncope, headache and suicide, and completed the MIDAS and HADS questionnaires. Genetic data were available for a subset of participants. Risk of syncope in relation to participant\u2019s characteristics and migraine susceptibility loci, and risks of psychological disorders associated with syncope, were calculated using logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Underweight, regular tea intake, diabetes mellitus, and migraine with aura were associated with increased syncope risks, with adjusted ORs of 1.76 (95% CI 1.03\u20133.03), 1.84 (95% CI 1.22\u20132.79), 4.70 (95% CI 1.58\u201313.95), and 1.78 (95% CI 1.03\u20133.10), respectively. Preliminary results showed that rs11172113 in LRP1 was associated with syncope risks. Comorbid syncope in migraine patients was associated with increased risks of depression (OR 1.95, 95% CI 1.18\u20133.22) and suicide attempt (OR 2.85, 95% CI 1.48\u20135.48).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study showed the potential roles of vascular risk factors in the association between migraine and syncope. Modifiable risk factors for syncope in patients with migraine include body mass index and tea intake. The debilitating psychological impact of co-morbid syncope in migraine patients warrants clinical attention of treating physicians.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102419865253","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:44:56Z","timestamp":1563237896000},"page":"1838-1846","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk factors and psychological impact of syncope in migraine patients"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4776-0464","authenticated-orcid":false,"given":"Ai Seon","family":"Kuan","sequence":"first","affiliation":[{"name":"Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"},{"name":"Institute of Public Health, National Yang-Ming University, Taipei"},{"name":"Division of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Pin","family":"Chen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei"},{"name":"Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei"},{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei"},{"name":"Division of Translational Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei"},{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Ling","family":"Fuh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei"},{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-3738","authenticated-orcid":false,"given":"Kuan-Po","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"},{"name":"Brain Research Center, National Yang-Ming University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-5358","authenticated-orcid":false,"given":"Shuu-Jiun","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei"},{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei"},{"name":"Brain Research Center, National Yang-Ming University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"bibr1-0333102419865253","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.23"},{"key":"bibr2-0333102419865253","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000204186.43597.66"},{"key":"bibr3-0333102419865253","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2000.00652.x"},{"key":"bibr4-0333102419865253","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417742375"},{"key":"bibr5-0333102419865253","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3598"},{"key":"bibr6-0333102419865253","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(91)90005-T"},{"key":"bibr7-0333102419865253","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.7.1062"},{"key":"bibr8-0333102419865253","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1007\/s100720300052","volume":"24","author":"D\u2019Amico D","year":"2003","journal-title":"Neurol Sci"},{"key":"bibr9-0333102419865253","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-004-0263-y"},{"key":"bibr10-0333102419865253","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.570044"},{"key":"bibr11-0333102419865253","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318293e1c7"},{"key":"bibr12-0333102419865253","doi-asserted-by":"crossref","unstructured":"The International Classification of Headache Disorders, 3rd edition (beta version).\n                      Cephalalgia\n                      2013; 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