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This was shown in the NO-triggered and also in the preictal stage of native human migraine attacks. Another headache type that is clinically even more suggestive of hypothalamic involvement is cluster headache, and indeed a structure in close proximity to the hypothalamus has been identified to play a crucial role in attack generation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It is very likely that spontaneous oscillations of complex networks involving the hypothalamus, brainstem, and dopaminergic networks lead to changes in susceptibility thresholds that ultimately start but also terminate headache attacks. We will review clinical and neuroscience evidence that puts the hypothalamus in the center of scientific attention when attack generation is discussed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102419867280","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T21:27:07Z","timestamp":1567114027000},"page":"1710-1719","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":152,"title":["Hypothalamic regulation of headache and migraine"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3499-1506","authenticated-orcid":false,"given":"Arne","family":"May","sequence":"first","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Burstein","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical center, Department of Anesthesia, Harvard medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"bibr1-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199902000-00001"},{"key":"bibr2-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410100102"},{"key":"bibr3-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr4-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417726498"},{"key":"bibr5-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100001694"},{"key":"bibr6-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199605170-00001"},{"key":"bibr7-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412467513"},{"key":"bibr8-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-008-0025-2"},{"key":"bibr9-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1993.1305309.x"},{"key":"bibr10-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91140-4"},{"key":"bibr11-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415620251"},{"key":"bibr12-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000052998.58526.A9"},{"key":"bibr13-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04168.x"},{"key":"bibr14-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01157.x"},{"key":"bibr15-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01195.x"},{"key":"bibr16-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01854.x"},{"key":"bibr17-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0495-7"},{"key":"bibr18-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002789"},{"key":"bibr19-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000310"},{"key":"bibr20-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.01026.x"},{"key":"bibr21-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-2866-0"},{"key":"bibr22-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414550108"},{"key":"bibr23-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01503.x"},{"key":"bibr24-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1111\/head.13195"},{"key":"bibr25-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00858.x"},{"key":"bibr26-0333102419867280","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1212\/WNL.53.1.3","volume":"53","author":"Silberstein S","year":"1999","journal-title":"Neurology"},{"key":"bibr27-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283378d5c"},{"key":"bibr28-0333102419867280","first-page":"223","volume":"41","author":"Mayanagi Y","year":"1978","journal-title":"Appl Neurophysiol"},{"key":"bibr29-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1080\/1025389031000092313"},{"key":"bibr30-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.05.015"},{"key":"bibr31-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00842.x"},{"key":"bibr32-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-014-0318-1"},{"key":"bibr33-0333102419867280","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.10.022"},{"key":"bibr34-0333102419867280","doi-asserted-by":"crossref","unstructured":"Bartsch T, Levy MJ, Knight YE, et al. 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