{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:57Z","timestamp":1787018817776,"version":"build-2736575974"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["fellowship No. 409865"],"award-info":[{"award-number":["fellowship No. 409865"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007819","name":"Allergan plc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Vidi grant 917.113.349"],"award-info":[{"award-number":["Vidi grant 917.113.349"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine has been associated with a dysfunctional activation of the trigeminovascular system. Calcitonin gene-related peptide, a neuropeptide released from the trigeminal nerve fibres, has an important role in the pathophysiology of migraine and is a current therapeutic target for migraine treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined the effects of two novel calcitonin gene-related peptide receptor antagonists, ubrogepant and atogepant, on the relaxations induced by \u03b1 calcitonin gene-related peptide in human isolated middle meningeal, cerebral and coronary arteries. Furthermore, the contractile responses to atogepant and ubrogepant per se were studied and compared to the responses elicited by zolmitriptan in proximal and distal human coronary arteries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In intracranial arteries, both blockers antagonized the calcitonin gene-related peptide-induced relaxations more potently when compared to the inhibition observed in distal human coronary arteries, with atogepant showing a higher potency. When analysing their antagonistic profile in HCA, ubrogepant showed a competitive antagonist profile, while atogepant showed a non-competitive one. Neither of the gepants had vasoconstrictor effect at any of the concentrations studied in human coronary arteries, whereas zolmitriptan elicited concentration-dependent contractions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ubrogepant and atogepant differentially inhibit the calcitonin gene-related peptide-dependent vasodilatory responses in intracranial arteries when compared to distal human coronary arteries. Also, both gepants are devoid of vasoconstrictive properties in human coronary arteries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102419884943","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T07:43:04Z","timestamp":1572594184000},"page":"357-366","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":63,"title":["Characterisation of the calcitonin gene-related peptide receptor antagonists ubrogepant and atogepant in human isolated coronary, cerebral and middle meningeal arteries"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-3632","authenticated-orcid":false,"given":"Elo\u00edsa","family":"Rubio-Beltran","sequence":"first","affiliation":[{"name":"Division of Pharmacology, Department of Internal Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Yi","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Department of Internal Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AH Jan","family":"Danser","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Department of Internal Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"MaassenVanDenBrink","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Department of Internal Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Edvinsson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Clinical Sciences, Lund University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,11,1]]},"reference":[{"key":"bibr1-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1111\/head.13081"},{"key":"bibr2-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.09.007"},{"key":"bibr3-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.15.5731"},{"key":"bibr4-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010917"},{"key":"bibr5-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70067-X"},{"key":"bibr6-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70198-4"},{"key":"bibr7-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410362122"},{"key":"bibr8-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280213"},{"key":"bibr9-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00310.x"},{"key":"bibr10-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030505"},{"key":"bibr11-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000286940.29755.61"},{"key":"bibr12-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2012.681044"},{"key":"bibr13-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416653233"},{"key":"bibr14-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1111\/head.13417"},{"key":"bibr15-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2019.1618830"},{"key":"bibr16-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1549223"},{"key":"bibr17-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0003-1"},{"key":"bibr18-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0807-1"},{"key":"bibr19-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2013"},{"key":"bibr20-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0979-y"},{"key":"bibr21-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.06.002"},{"key":"bibr22-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0811-5"},{"key":"bibr23-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.165993"},{"key":"bibr24-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00830.x"},{"key":"bibr25-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.10.001"},{"key":"bibr26-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.1.25"},{"key":"bibr27-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.41.1.19"},{"key":"bibr28-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1959.tb00928.x"},{"key":"bibr29-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-018-0524-7"},{"key":"bibr30-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109781"},{"key":"bibr31-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2014.03.001"},{"key":"bibr32-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554909"},{"key":"bibr33-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-014-0524-1"},{"key":"bibr34-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002465"},{"key":"bibr35-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38302.504063.8F"},{"key":"bibr36-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12618"},{"key":"bibr37-0333102419884943","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.11.020"},{"key":"bibr38-0333102419884943","first-page":"1257","volume":"58","author":"Maassen 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