{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:29:26Z","timestamp":1777490966470,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Lundbeck Foundation"},{"DOI":"10.13039\/501100013826","name":"The Candys Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Levcromakalim opens ATP-sensitive potassium channels (K\n                      <jats:sub>ATP<\/jats:sub>\n                      channel) and induces head pain in healthy volunteers and migraine headache in migraine patients, but no pain in other parts of the body. K\n                      <jats:sub>ATP<\/jats:sub>\n                      channels are expressed in C- and A\u03b4-fibers, and these channels might directly activate nociceptors and thereby evoke pain in humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To assess the local effect of K\n                      <jats:sub>ATP<\/jats:sub>\n                      channel opening in trigeminal and extra-trigeminal regions, we performed a crossover, double-blind, placebo-controlled study in healthy volunteers. Participants received intradermal and intramuscular injections of levcromakalim and placebo in the forehead and the forearms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intradermal and intramuscular injections of levcromakalim did not evoke more pain compared to placebo in the forehead ( p\u2009&gt;\u20090.05) and the forearms ( p\u2009&gt;\u20090.05). Intradermal injection of levcromakalim caused more flare ( p\u2009&lt;\u20090.001 ), skin temperature increase ( p\u2009&lt;\u20090.001), and skin blood flow increase ( p\u2009&lt;\u20090.001) compared to placebo in the forehead and the forearms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that it is unlikely that levcromakalim induces head pain by direct activation of peripheral neurons.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102419888490","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T06:07:01Z","timestamp":1573106821000},"page":"1789-1797","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Extracranial activation of ATP-sensitive potassium channels induces vasodilation without nociceptive effects"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-9665","authenticated-orcid":false,"given":"Mohammad Al-Mahdi","family":"Al-Karagholi","sequence":"first","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7954-8519","authenticated-orcid":false,"given":"Hashmat","family":"Ghanizada","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob M\u00f8ller","family":"Hansen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameera","family":"Aghazadeh","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene Theil","family":"Skovgaard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes","family":"Olesen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark"},{"name":"Glostrup Research Park, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"bibr1-0333102419888490","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703038"},{"key":"bibr2-0333102419888490","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.01.045"},{"key":"bibr3-0333102419888490","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.01.103"},{"key":"bibr4-0333102419888490","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.04.076"},{"key":"bibr5-0333102419888490","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.07.026"},{"key":"bibr6-0333102419888490","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-04-03065.1995"},{"key":"bibr7-0333102419888490","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059829"},{"key":"bibr8-0333102419888490","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.01.103"},{"key":"bibr9-0333102419888490","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308382101"},{"key":"bibr10-0333102419888490","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03365.x"},{"key":"bibr11-0333102419888490","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182194bd3"},{"key":"bibr12-0333102419888490","doi-asserted-by":"crossref","unstructured":"Vergoni AV, Scarano A, Bertolini A. 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