{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:29:47Z","timestamp":1777490987629,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V100E6-001"],"award-info":[{"award-number":["V100E6-001"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V106C-117"],"award-info":[{"award-number":["V106C-117"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 104-2314-B-010-015-MY2"],"award-info":[{"award-number":["MOST 104-2314-B-010-015-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 104-2314-B-075-006 -MY3"],"award-info":[{"award-number":["MOST 104-2314-B-075-006 -MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 105-2320-B-039-055-MY3"],"award-info":[{"award-number":["MOST 105-2320-B-039-055-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 105-2811-B-039-026"],"award-info":[{"award-number":["MOST 105-2811-B-039-026"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 106-2320-B-039-053"],"award-info":[{"award-number":["MOST 106-2320-B-039-053"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 106-2811-B-039-014"],"award-info":[{"award-number":["MOST 106-2811-B-039-014"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107-2314-B-010-021"],"award-info":[{"award-number":["MOST 107-2314-B-010-021"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW 103-TDU-B-211-113-003"],"award-info":[{"award-number":["MOHW 103-TDU-B-211-113-003"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW 104-TDU-B-211-113-003"],"award-info":[{"award-number":["MOHW 104-TDU-B-211-113-003"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW 105-TDU-B-211-113-003"],"award-info":[{"award-number":["MOHW 105-TDU-B-211-113-003"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The pathophysiology of reversible cerebral vasoconstriction syndrome is unclear. An unbiased systems-based approach might help to illustrate the metabolite profiling and underlying pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Urine samples were collected from reversible cerebral vasoconstriction syndrome patients and matched controls recruited in Taipei Veterans General Hospital.\n                      <jats:sup>1<\/jats:sup>\n                      H-Nuclear magnetic resonance was used to initially explore the metabolic profile, and liquid chromatography tandem mass spectrometry was then used to identify metabolic alterations in reversible cerebral vasoconstriction syndrome. Untargeted metabolite screening was randomly performed on 10 reversible cerebral vasoconstriction syndrome patients and 10 control subjects in the discovery phase. The selected untargeted metabolites were further validated on 47 reversible cerebral vasoconstriction syndrome patients during their ictal stage (with 40 of them having remission samples) and 47 controls in the replication phase.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and conclusion<\/jats:title>\n                    <jats:p>Six metabolites-hippurate, citrate, 1,3,7-trimethyluric acid, ascorbic acid, D-glucurono-6,3-lactone, and D- threo-isocitric acid-with t-test derived p-value &lt; 0.05 and VIP score &gt;1, were identified as potential urine signatures that can well distinguish reversible cerebral vasoconstriction syndrome subjects at ictal stage from controls. Among them, citrate, hippurate, ascorbic acid, and D-glucurono-6,3-lactone were significantly lower, and 1,3,7-trimethyluric acid and D- threo-isocitric acid were higher in reversible cerebral vasoconstriction syndrome patients. Of these, four selected metabolites, citrate, D-glucurono-6,3-lactone, ascorbic acid, and 1,3,7-trimethyluric acid, returned to normal levels in remission. These metabolites are related to pathways associated with free radical scavenging, with the hub molecules being associated with endothelial dysfunction or sympathetic overactivity. Whether these metabolites and their implicated networks play a role in the pathogenesis of reversible cerebral vasoconstriction syndrome remains to be confirmed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102419897621","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T22:43:42Z","timestamp":1578437022000},"page":"735-747","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Urine metabolomics signatures in reversible cerebral vasoconstriction syndrome"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5468-5859","authenticated-orcid":false,"given":"Wei-Hsiang","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-5358","authenticated-orcid":false,"given":"Shuu-Jiun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei"},{"name":"Brain Research Center, National Yang-Ming University, Taipei"},{"name":"Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei"},{"name":"Institute of Brain Science, National Yang-Ming University, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Ming","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Jung","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Integrated Medicine, China Medical University, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei"},{"name":"Brain Research Center, National Yang-Ming University, Taipei"},{"name":"Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Ling","family":"Fuh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei"},{"name":"Brain Research Center, National Yang-Ming University, Taipei"},{"name":"Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-9902","authenticated-orcid":false,"given":"Shih-Pin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei"},{"name":"Brain Research Center, National Yang-Ming University, Taipei"},{"name":"Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei"},{"name":"Division of Translational Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei"},{"name":"Institute of Clinical Medicine, National Yang-Ming University, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Lian","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung"},{"name":"Department of Pharmacy, National Taiwan University, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"bibr1-0333102419897621","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-1-200701020-00007"},{"key":"bibr2-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70135-7"},{"key":"bibr3-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000249115.63436.6d"},{"key":"bibr4-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm256"},{"key":"bibr5-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.68"},{"key":"bibr6-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21384"},{"key":"bibr7-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21951"},{"key":"bibr8-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24652"},{"key":"bibr9-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412437387"},{"key":"bibr10-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1321"},{"key":"bibr11-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001473"},{"key":"bibr12-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1586\/ern.11.112"},{"key":"bibr13-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-94"},{"key":"bibr14-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.04.022"},{"key":"bibr15-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-82"},{"key":"bibr16-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018024"},{"key":"bibr17-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.08.013"},{"key":"bibr18-0333102419897621","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition.\n                      Cephalalgia\n                      2018; 38: 1\u2013211.","DOI":"10.1177\/0333102417738202"},{"key":"bibr19-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-011-0394-0"},{"key":"bibr20-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1021\/ac8024569"},{"key":"bibr21-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1021\/ac8019366"},{"key":"bibr22-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1021\/ac303233c"},{"key":"bibr23-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-011-0347-7"},{"key":"bibr24-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky310"},{"key":"bibr25-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.12.019"},{"key":"bibr26-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.10.008"},{"key":"bibr27-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.10.025"},{"key":"bibr28-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05607.x"},{"key":"bibr29-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/8.3.369"},{"key":"bibr30-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000040860.71626.9D"},{"key":"bibr31-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1991.tb03204.x"},{"key":"bibr32-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01484-9"},{"key":"bibr33-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000120669.85649.77"},{"key":"bibr34-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1586\/14789450.2015.1094380"},{"key":"bibr35-0333102419897621","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3154"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102419897621","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102419897621","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102419897621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:48:31Z","timestamp":1777387711000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102419897621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1177\/0333102419897621"],"URL":"https:\/\/doi.org\/10.1177\/0333102419897621","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,7]]}}}