{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:24:06Z","timestamp":1791300246605,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dopaminergic symptoms may be extremely pronounced in some migraine patients during the attack, representing a major source of disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to carefully characterize the clinical picture of migraine patients with dopaminergic symptoms in a large patients\u2019 population as a putative migraine endophenotype, allowing more precise disease management, treatment and outcome prediction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We screened 1148 consecutive tertiary care episodic and chronic migraine patients with face-to-face interviews collecting thorough data on lifestyle, socio-demographic factors, and clinical migraine features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 374 patients with migraine with dopaminergic symptoms (32.6%). The most frequent dopaminergic symptom was yawning followed by somnolence, nausea, vomiting, fatigue, mood changes and diuresis. Migraine patients with dopaminergic symptoms had longer attack duration (OR: 1.82; 95% CI: 1.41\u20132.36, p\u2009&lt;\u20090.0001), more frequent osmophobia (OR: 2.01; 95% CI: 1.50\u20132.69, p\u2009&lt;\u20090.0001), allodynia (OR: 1.43; 95% CI: 1.10\u20131.85, p\u2009=\u20090.0071) and unilateral cranial autonomic symptoms (OR: 1.31; 95% CI: 1.01\u20131.68, p\u2009=\u20090.045), but used less preventative treatments (OR: 0.74; 95% CI: 0.57\u20130.98, p\u2009=\u20090.033) than patients without dopaminergic symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Migraine patients with dopaminergic symptoms are characterized by a full-blown, more disabling migraine. Dopaminergic system modulation should be carefully considered in individuals with migraine with dopaminergic symptoms for both acute and preventative treatments in future ad hoc designed studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102420929023","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T09:16:15Z","timestamp":1591089375000},"page":"1168-1176","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Dopaminergic symptoms in migraine: A cross-sectional study on 1148 consecutive headache center-based patients"],"prefix":"10.1177","volume":"40","author":[{"given":"Piero","family":"Barbanti","sequence":"first","affiliation":[{"name":"Headache and Pain Unit, IRCCS San Raffaele Pisana, Rome, Italy"},{"name":"Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Aurilia","sequence":"additional","affiliation":[{"name":"Headache and Pain Unit, IRCCS San Raffaele Pisana, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Egeo","sequence":"additional","affiliation":[{"name":"Headache and Pain Unit, IRCCS San Raffaele Pisana, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Fofi","sequence":"additional","affiliation":[{"name":"Headache and Pain Unit, IRCCS San Raffaele Pisana, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorella","family":"Guadagni","sequence":"additional","affiliation":[{"name":"Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy"},{"name":"InterInstitutional Multidisciplinary Biobank (BioBIM), IRCCS San Raffaele Pisana, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Ferroni","sequence":"additional","affiliation":[{"name":"Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy"},{"name":"InterInstitutional Multidisciplinary Biobank (BioBIM), IRCCS San Raffaele Pisana, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"bibr1-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-005-0143-8"},{"key":"bibr2-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1415-8"},{"key":"bibr3-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/3.6.59S"},{"key":"bibr4-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.03.024"},{"key":"bibr5-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.16"},{"key":"bibr6-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1977.hed1703129.x"},{"key":"bibr7-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283378d5c"},{"key":"bibr8-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00313.x"},{"key":"bibr9-0333102420929023","first-page":"23","volume":"6","author":"Bussone G","year":"1986","journal-title":"Int J Clin Pharmacol Res"},{"key":"bibr10-0333102420929023","first-page":"189","volume":"6","author":"Bes A","year":"1986","journal-title":"Int J Clin Pharmacol Res"},{"key":"bibr11-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12491-5"},{"key":"bibr12-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2000.00001.x"},{"key":"bibr13-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1111\/head.13083"},{"key":"bibr14-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.3.781"},{"key":"bibr15-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003861"},{"key":"bibr16-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr17-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416630579"},{"key":"bibr18-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.31"},{"key":"bibr19-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-012-0440-y"},{"key":"bibr20-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1111\/head.12498"},{"key":"bibr21-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1111\/head.13635"},{"key":"bibr22-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(82)90136-8"},{"key":"bibr23-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2887-09.2009"},{"key":"bibr24-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199702000-00004"},{"key":"bibr25-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1980.hed2002099.x"},{"key":"bibr26-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-011-0150-9"},{"key":"bibr27-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1978.hed1802075.x"},{"key":"bibr28-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.1.101"},{"key":"bibr29-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1999.3906426.x"},{"key":"bibr30-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.12.002"},{"key":"bibr31-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413480755"},{"key":"bibr32-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx056"},{"key":"bibr33-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0373-15.2015"},{"key":"bibr34-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-5147-7"},{"key":"bibr35-0333102420929023","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1903-5"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102420929023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102420929023","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102420929023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:48:41Z","timestamp":1777387721000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102420929023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,2]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1177\/0333102420929023"],"URL":"https:\/\/doi.org\/10.1177\/0333102420929023","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,2]]}}}