{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:10:11Z","timestamp":1780733411119,"version":"3.54.1"},"reference-count":88,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I0RX002101"],"award-info":[{"award-number":["1I0RX002101"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["NS075599"],"award-info":[{"award-number":["NS075599"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["NS098825"],"award-info":[{"award-number":["NS098825"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Calcitonin gene-related peptide is recognized as a key player in migraine, yet the mechanisms and sites of calcitonin gene-related peptide action remain unknown. The efficacy of calcitonin gene-related peptide-blocking antibodies as preventative migraine drugs supports a peripheral site of action, such as the trigeminovasculature. Given the apparent disconnect between the importance of vasodilatory peptides in migraine and the prevailing opinion that vasodilation is an epiphenomenon, the goal of this study was to test whether vasodilation plays a role in calcitonin gene-related peptide-induced light aversive behavior in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Systemic mean arterial pressure and light aversive behavior were measured after intraperitoneal administration of calcitonin gene-related peptide and vasoactive intestinal peptide in wild-type CD1 mice. The functional significance of vasodilation was tested by co-administration of a vasoconstrictor (phenylephrine, endothelin-1, or caffeine) with calcitonin gene-related peptide to normalize blood pressure during the light aversion assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both calcitonin gene-related peptide and vasoactive intestinal peptide induced light aversion that was associated with their effect on mean arterial pressure. Notably, vasoactive intestinal peptide caused relatively transient vasodilation and light aversion. Calcitonin gene-related peptide-induced light aversion was still observed even with normalized blood pressure. However, two of the agents, endothelin-1 and caffeine, did reduce the magnitude of light aversion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We propose that perivascular calcitonin gene-related peptide causes light-aversive behavior in mice by both vasomotor and non-vasomotor mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102420949173","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T01:04:19Z","timestamp":1597799059000},"page":"1585-1604","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Vascular actions of peripheral CGRP in migraine-like photophobia in mice"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7674-1313","authenticated-orcid":false,"given":"Bianca N","family":"Mason","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"},{"name":"Brain and Behavior Sciences, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4392-2211","authenticated-orcid":false,"given":"Anne-Sophie","family":"Wattiez","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"},{"name":"Center for the Prevention and Treatment of Visual Loss, Veterans Administration Health Center, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis K","family":"Balcziak","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"},{"name":"Neuroscience Program, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adisa","family":"Kuburas","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Kutschke","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine and Francois M Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"},{"name":"Center for the Prevention and Treatment of Visual Loss, Veterans Administration Health Center, Iowa City, IA, USA"},{"name":"Department of Neurology, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"bibr1-0333102420949173","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.012"},{"key":"bibr2-0333102420949173","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00233"},{"key":"bibr3-0333102420949173","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2019.10.013"},{"key":"bibr4-0333102420949173","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418771350"},{"key":"bibr5-0333102420949173","doi-asserted-by":"publisher","DOI":"10.1080\/09647049209525535"},{"key":"bibr6-0333102420949173","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1938.02270040093005"},{"key":"bibr7-0333102420949173","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1955.02330140015003"},{"key":"bibr8-0333102420949173","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1967.00470230096013"},{"key":"bibr9-0333102420949173","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.10.2.107"},{"key":"bibr10-0333102420949173","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f9626a"},{"key":"bibr11-0333102420949173","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/0333102489009S1016","volume":"9","author":"Humphrey PP","year":"1989","journal-title":"GR43175. 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