{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:58Z","timestamp":1787018818721,"version":"build-2736575974"},"reference-count":61,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100003965","name":"Migraine Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003965","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>The importance of neck pain and the trigeminocervical complex in migraine is of high pathophysiological interest since a block to the greater occipital nerve is more effective for some primary headaches than others. This observational study hypothesised that the response to manual palpation of the upper cervical spine predicts the efficacy of the greater occipital nerve-block.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We divided patients, scheduled by a neurologist to receive a greater occipital nerve-block to reduce their migraine symptoms, into three groups: Patients with no pain response to manual palpation of the neck, patients with local pain, and those with referred pain to the head. Primary outcome was the percentage change in headache frequency. Additionally, items from the quantitative sensory testing protocol were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty-seven chronic migraine patients were recruited consecutively from a specialised outpatient clinic and 71 were included for analyses and stratified into the three groups: No pain (n\u2009=\u200911), local pain (n\u2009=\u200928), and referred pain to the head (n\u2009=\u200932). Overall, patients experienced a reduction of 1.9 headache days per month (SD 3.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090,0001). The groups differed significantly in the percentage change of headache frequency (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041) with the \u201cno pain\u201d group showing the largest reduction. The pressure-pain-threshold over C2 and headache on the day of the intervention influenced the outcome significantly (R\n                      <jats:sup>2<\/jats:sup>\n                      0,27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090,00078). No serious adverse events occurred. Sixty-five percent of the patients had headaches during the examination. The groups did not differ regarding the distribution of patients with neck-pain in absence of migraine at baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.618).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients that were less sensitive to palpation in the cervical region and headache-free on the day of the intervention improved more after the greater occipital nerve-block.<\/jats:p>\n                    <jats:p>\n                      Registration: Registered\n                      <jats:italic>a priori<\/jats:italic>\n                      at the German Clinical Trials Register (DRKS00015995).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102420954518","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:12:33Z","timestamp":1598919153000},"page":"78-89","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Predicting the outcome of the greater occipital nerve block \u2013 an observational study on migraine patients with and without musculoskeletal cervical impairment"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4537-8563","authenticated-orcid":false,"given":"Annika","family":"Schwarz","sequence":"first","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"},{"name":"Department of Health Sciences, Academic Physiotherapy, Pain and Exercise Research Luebeck (P.E.R.L), University of Luebeck, Luebeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-4239","authenticated-orcid":false,"given":"Christian","family":"Ziegeler","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Daneshkhah","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3499-1506","authenticated-orcid":false,"given":"Arne","family":"May","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Luedtke","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"},{"name":"Department of Health Sciences, Academic Physiotherapy, Pain and Exercise Research Luebeck (P.E.R.L), University of Luebeck, Luebeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414535110"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0566-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000225186.76323.69"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01608.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417716934"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.math.2016.02.010"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2013.11.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20805"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf166"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70186-7"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418821669"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.016"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12716"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12393"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2017.08.027"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414561872"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2153-18.2018"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20150345"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2004.34.11.686"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0808-0"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419877171"},{"key":"e_1_3_3_25_2","article-title":"Prevalence of occipital neuralgia at a community hospital-based headache clinic","author":"Mathew PG","unstructured":"Mathew PG, Najib U, Khaled S, et\u00a0al. Prevalence of occipital neuralgia at a community hospital-based headache clinic. Neurol Clin Pract. Epub ahead of print 12 December 2019. DOI: 10.1212\/CPJ.0000000000000789.","journal-title":"Neurol Clin Pract"},{"key":"e_1_3_3_26_2","first-page":"480","volume-title":"Maitland\u2019s vertebral manipulation: Management of neuromusculoskeletal disorders \u2013 volume 1","author":"Hengeveld E","year":"2013","unstructured":"Hengeveld E, Banks K. Maitland\u2019s vertebral manipulation: Management of neuromusculoskeletal disorders \u2013 volume 1, 8th edn. London: Churchill Livingstone; 2013, p. 480.","edition":"8"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02169.x"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.02.003"},{"key":"e_1_3_3_29_2","unstructured":"Rolke R Andrews K Magerl W et\u00a0al. A standardized battery of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS) Version 2.1. 2010. Chair of Neurophysiology University Medicine Mannheim; Heidelberg University. https:\/\/www.neuro.med.tu-muenchen.de\/dfns\/pdfs\/QST-Investigators_brochure_Version_2_1_final_english_2010_07_09.pdf (accessed 22 August 2020)."},{"key":"e_1_3_3_30_2","first-page":"337","article-title":"Identification of greater occipital nerve landmarks for the treatment of occipital neuralgia","volume":"65","author":"Loukas M","year":"2006","unstructured":"Loukas M, El-Sedfy A, Tubbs RS, et\u00a0al. Identification of greater occipital nerve landmarks for the treatment of occipital neuralgia. Folia Morphol 2006; 65: 337\u2013342.","journal-title":"Folia Morphol"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ca.20297"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2005.05073.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz052"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000183358.53939.38"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.suppl_1.S20"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12420"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-15-91"},{"key":"e_1_3_3_38_2","first-page":"409","article-title":"The Neck Disability Index: A study of reliability and validity.","volume":"14","author":"Vernon H","year":"1991","unstructured":"Vernon H, Mior S. The Neck Disability Index: A study of reliability and validity. J Manipulative Physiol Ther 1991; 14: 409\u2013415.","journal-title":"J Manipulative Physiol Ther"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1026\/0012-1924.50.4.171"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1179\/jmt.2009.17.3.163"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v4.i10.323"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.124420"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416655159"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410364676"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13023"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417752119"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0630-0"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001531"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001231"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00602.x"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1159\/000085060"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21211"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjpt.2019.11.001"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzz007"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001353"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-1083-z"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1080\/10669817.2017.1300397"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2018-100306"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419896369"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102420954518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102420954518","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102420954518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:48:52Z","timestamp":1777387732000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102420954518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,31]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/0333102420954518"],"URL":"https:\/\/doi.org\/10.1177\/0333102420954518","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,31]]}}}