{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:24:16Z","timestamp":1784233456415,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess whether erenumab influences cerebral vasomotor reactivity and flow-mediated dilation in migraine patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive migraineurs prescribed erenumab at our Headache Centre and age and sex-matching controls were invited to participate in this observational longitudinal study. Patients were evaluated for cerebral vasomotor reactivity to hypercapnia (breath-holding index) in middle and posterior cerebral arteries and for brachial corrected flow mediated dilation at baseline (T0), after 2 weeks from the first erenumab injection (T2) and after 2 weeks from the fourth Erenumab injection (T18). Patients displaying a reduction of at least 50% in monthly migraine days after completing the fourth month of therapy were classified as responders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty patients and 25 controls agreed to participate. Middle and posterior cerebral artery mean flow velocities, breath-holding index and flow-mediated dilation did not differ at T0 and from T0 to T2 in patients and controls. In patients, we neither observed a variation of the explored variables from T0 to T18 nor an interaction between evaluation times (T0\u2013T2 or T0\u2013T18) and chronic condition at T0, responder state or erenumab fourth dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate that erenumab preserves cerebral vasomotor reactivity and flow-mediated dilation in migraineurs without aura.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102420956692","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:12:33Z","timestamp":1598919153000},"page":"90-98","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Erenumab does not alter cerebral hemodynamics and endothelial function in migraine without aura"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-5535","authenticated-orcid":false,"given":"Claudia","family":"Altamura","sequence":"first","affiliation":[{"name":"Headache and Neurosonology Unit, Neurology, Campus Bio-Medico University Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Viticchi","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Marche Polytechnic University, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Fallacara","sequence":"additional","affiliation":[{"name":"Headache and Neurosonology Unit, Neurology, Campus Bio-Medico University Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelina Maria","family":"Costa","sequence":"additional","affiliation":[{"name":"Headache and Neurosonology Unit, Neurology, Campus Bio-Medico University Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Brunelli","sequence":"additional","affiliation":[{"name":"Headache and Neurosonology Unit, Neurology, Campus Bio-Medico University Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fiori","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Marche Polytechnic University, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Silvestrini","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Marche Polytechnic University, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-9336","authenticated-orcid":false,"given":"Fabrizio","family":"Vernieri","sequence":"additional","affiliation":[{"name":"Headache and Neurosonology Unit, Neurology, Campus Bio-Medico University Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.13300"},{"key":"e_1_3_3_3_2","article-title":"Effect of stimulation of trigeminal ganglion on regional cerebral blood flow in cats","volume":"253","author":"Goadsby PJ","year":"1987","unstructured":"Goadsby PJ, Duckworth JW. 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