{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:32:46Z","timestamp":1791725566373,"version":"4.3.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta-analysis evaluates pressure pain sensitivity values in symptomatic and\n            distant pain-free areas comparing individuals with tension-type headache to\n            controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Databases and data treatment<\/jats:title>\n                    <jats:p>Electronic databases were searched for cross-sectional or prospective case-control\n            studies comparing pressure pain thresholds in patients with tension-type headache to\n            headache-free controls. Data were extracted by three reviewers. The methodological\n            quality was assessed by the Newcastle-Ottawa Quality Assessment Scale. Meta-analyses of\n            trigeminal, extra-trigeminal (neck) and distant pain-free areas in tension-type headache\n            were compared to headache-free controls. Frequency of tension-type headache and gender\n            were taken into account.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty studies were included. Patients with tension-type headache exhibited lower\n            pressure pain thresholds than headache-free controls: Trigeminal (MD \u221249.11 kPa, 95% CI\n            \u221266.05 to \u221232.17), cervical spine (MD \u221288.17 kPa, 95% CI \u2212108.43 to \u221267.92) and distant\n            pain-free areas (MD \u221298.43 kPa, 95% CI \u2212136.78 to \u221260.09). Differences were significant\n            for chronic, episodic, and mixed episodic and chronic tension-type headache within the\n            trigeminal and neck (symptomatic areas), but only significant for chronic tension-type\n            headache (MD \u2212102.86, 95% CI \u2212139.47 to \u221266.25 kPa) for distant pain-free areas. In\n            general, women had lower pressure pain thresholds than men. The methodological quality\n            ranged from fair (45%) to good (40%). The results showed a high heterogeneity and\n            publication bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This first meta-analysis addressing pressure pain thresholds differences in symptomatic\n            and distant pain-free areas between patients with tension-type headache and controls\n            found low to moderate evidence supporting the presence of pressure pain hypersensitivity\n            in the trigeminal and neck areas in tension-type headache in comparison with\n            headache-free controls. Sensitivity to pressure pain was widespread only in chronic, not\n            episodic, tension-type headache (moderate evidence).<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Registration number:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.17605\/OSF.IO\/R29HY\">https:\/\/doi.org\/10.17605\/OSF.IO\/R29HY<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102420958384","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T03:39:15Z","timestamp":1600745955000},"page":"256-273","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Evidence of localized and widespread pressure pain hypersensitivity in          patients with tension-type headache: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3772-9690","authenticated-orcid":false,"given":"C\u00e9sar","family":"Fern\u00e1ndez-de-las-Pe\u00f1as","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Occupational Therapy, Physical Medicine\r          and Rehabilitation, Universidad Rey Juan Carlos (URJC), Alcorc\u00f3n, Madrid, Spain"},{"name":"C\u00e1tedra Institucional en Docencia, Cl\u00ednica e Investigaci\u00f3n en\r          Fisioterapia: Terapia Manual, Punci\u00f3n Seca y Ejercicio Terap\u00e9utico, Universidad Rey Juan\r          Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Plaza-Manzano","sequence":"additional","affiliation":[{"name":"Radiology, Rehabilitation and Physiotherapy Department, Universidad\r          Complutense de Madrid, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos,\r          Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos J","family":"Navarro-Santana","sequence":"additional","affiliation":[{"name":"Radiology, Rehabilitation and Physiotherapy Department, Universidad\r          Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes","family":"Olesen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup,\r          Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rigmor H","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup,\r          Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup,\r          Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-31"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12339"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-40"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1370-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01095-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.13067"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-014-0469-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573397112666151231113625"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.030"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0004-9514(07)70032-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01768.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000219"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0833-7"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_3_2_18_2","first-page":"S1","article-title":". Classification and diagnostic criteria for headache disorders, cranial\n            neuralgias and facial pain","volume":"8","author":"Headache Classification Committee of the International Headache Society","year":"1988","unstructured":"Headache Classification Committee of the International Headache Society . Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 1988; 8: S1\u2013S96.","journal-title":"Cephalalgia"},{"key":"e_1_3_2_19_2","first-page":"8","article-title":"The International Classification\n            of Headache Disorders, 2nd edition","volume":"24","author":"Headache Classification Committee of the International Headache Society","year":"2004","unstructured":"Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders, 2nd edition. Cephalalgia 2004; 24: 8\u2013152.","journal-title":"Cephalalgia"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_3_2_22_2","unstructured":"Wells GA Tugwell P O\u2019Connell D et\u00a0al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. 2015 http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp (accessed 15 June 2020)."},{"key":"e_1_3_2_23_2","article-title":"Closing the quality gap: Revisiting the state of the\n            science (vol. 3: Quality improvement interventions to address health\n            disparities)","author":"McPheeters ML","unstructured":"McPheeters ML, Kripalani S, Peterson NB, et\u00a0al. Closing the quality gap: Revisiting the state of the science (vol. 3: Quality improvement interventions to address health disparities). Evid Rep Technol Assess (Full Rep) 2012; 208: 1\u2013475.","journal-title":"Evid Rep Technol Assess (Full Rep)"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ebm.13.6.162-a"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20130627"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90198-7"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90131-8"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.01005.x"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01772.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181a38f88"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01901.x"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01779.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12982"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2017.06.014"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1808-185120171602162637"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz146"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04384-8"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1994.1406451.x"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1999.1903174.x"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12565"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181a08747"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2000.00020.x"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550040113021"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1997.3709565.x"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2005.01023.x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.040"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01248.x"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31803b3770"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00114-X"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90131-8"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1163\/1568569053749976"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2011.3666"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001231"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.11.026"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.11.025"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102420958384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0333102420958384","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0333102420958384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:48:53Z","timestamp":1777387733000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0333102420958384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1177\/0333102420958384"],"URL":"https:\/\/doi.org\/10.1177\/0333102420958384","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,22]]}}}