{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:32:49Z","timestamp":1777491169705,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Recently, an additional trigeminothalamic tract \u2013 the dorsal trigeminothalamic tract \u2013 has been described in human brainstems by our group next to the known ventral trigeminothalamic tract. As various elements of the trigeminal system are known to be organised in a somatotopic fashion, the question arose whether the fibres within the trigeminal root show specific distributions patterns in their contribution to the ventral trigeminothalamic tract and dorsal trigeminothalamic tract specifically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study investigated the arrangement of the fibres in the trigeminal root by combining various imaging methods in the pons of 11 post-mortem specimens. The pons were investigated by polarised light imaging (PLI) (n\u2009=\u20094; to quantify fibre orientation; 100 \u00b5m interslice distance), histochemical staining methods (n\u2009=\u20093; to visualise the internal myeloarchitecture; 60 \u00b5m) and ultra-high field, post-mortem magnetic resonance imaging (MRI) (n\u2009=\u20094; for tractography; 500 \u00b5m interslice distance).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study shows that the fibres, from the point where the trigeminal root enters the brainstem, are distinctly arranged by their contribution to the ventral trigeminothalamic tract and dorsal trigeminothalamic tract. This finding is supported by both post-mortem, ultra-high dMRI and different light microscopy techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The data from this study suggest that the fibres in the superior half of the root contribute mainly to the ventral trigeminothalamic tract, whereas the fibres in the inferior half mainly contribute to the dorsal trigeminothalamic tract. Such a somatotopic organisation could possibly create new insights into the anatomical origin of trigeminal neuralgia and the clinical relevance of this somatotopic organisation should therefore be further explored.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102420959796","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:08:28Z","timestamp":1600819708000},"page":"1645-1656","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Mapping the trigeminal root entry zone and its pontine fibre distribution patterns"],"prefix":"10.1177","volume":"40","author":[{"given":"Alis","family":"Guberinic","sequence":"first","affiliation":[{"name":"Department of Radiology, Nuclear Medicine and Anatomy, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veerle","family":"Souverein","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nuclear Medicine and Anatomy, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Volkers","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nuclear Medicine and Anatomy, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"van Cappellen van Walsum","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nuclear Medicine and Anatomy, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris CP","family":"Vissers","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain and Palliative Care, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Mollink","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nuclear Medicine and Anatomy, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands"},{"name":"Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3915-3034","authenticated-orcid":false,"given":"Dylan JHA","family":"Henssen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nuclear Medicine and Anatomy, Radboud University Medical Center, Nijmegen, the 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