{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:22:26Z","timestamp":1791933746799,"version":"4.3.4"},"reference-count":71,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K01HL128791"],"award-info":[{"award-number":["K01HL128791"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["K24AT009282"],"award-info":[{"award-number":["K24AT009282"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Crimson Lion Foundation, Jeannie and Jonathan S. Lavine, Trustees"},{"DOI":"10.13039\/100014872","name":"Osher Center for Integrative Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014872","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Inter-Institutional Network for Chiropractic Research (IINCR) through Palmer College Foundation"},{"DOI":"10.13039\/100007517","name":"NCMIC Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007517","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spinal manipulation may reduce migraine frequency, but effects of multimodal chiropractic care on migraine frequency have not been evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a pilot randomized controlled trial comparing multimodal chiropractic care\u2009+\u2009enhanced usual care (MCC+) versus enhanced usual care alone (EUC) among adult women with episodic migraine. EUC was comprised of usual medical care and migraine education literature. MCC+ participants received 10 sessions of chiropractic care over 14 weeks. Primary aims evaluated feasibility of recruitment, retention, protocol adherence, and safety. Change in migraine days was a secondary aim.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 422 patients screened, 61 were randomized over 20 months. Fifty-seven (93%) completed daily migraine logs during the intervention, 51 (84%) completed final follow-up, and 45 (74%) completed all assessments. Twenty-four of 29 MCC+ participants (83%) attended\u2009&gt;\u200975% of the chiropractic sessions. Ninety-eight non-serious adverse events were reported by 26 participants (43%) with 39 events among 11 EUC participants and 59 events among 15 MCC+ participants. MCC+ participants experienced greater reductions in migraine days (\u22122.9 days for MCC+ vs. \u22121.0 days for EUC, difference\u2009=\u2009\u22121.9; 95% confidence interval: \u22123.5, \u22120.4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre-specified feasibility criteria were not met, but deficits were remediable. Preliminary data support a definitive trial of MCC+ for migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This study is registered at Clinicaltrials.gov (NCT03177616).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102420963844","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T01:02:16Z","timestamp":1602637336000},"page":"318-328","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Multimodal chiropractic care for migraine: A pilot randomized controlled trial"],"prefix":"10.1177","volume":"41","author":[{"given":"Pamela M","family":"Rist","sequence":"first","affiliation":[{"name":"Division of Preventive Medicine, Department of Medicine, Harvard Medical School and Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Bernstein","sequence":"additional","affiliation":[{"name":"John Graham Headache Center, Department of Neurology, Harvard Medical School and Brigham and Women\u2019s Hospital, Boston, MA, USA"},{"name":"Osher Clinical Center, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Osher Clinical Center, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Osypiuk","sequence":"additional","affiliation":[{"name":"Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie P","family":"Connor","sequence":"additional","affiliation":[{"name":"Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Vining","sequence":"additional","affiliation":[{"name":"Palmer College of Chiropractic, Davenport, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia R","family":"Long","sequence":"additional","affiliation":[{"name":"Palmer College of Chiropractic, Davenport, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A","family":"Macklin","sequence":"additional","affiliation":[{"name":"Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"Wayne","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Department of Medicine, Harvard Medical School and Brigham and Women\u2019s Hospital, Boston, MA, USA"},{"name":"Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"bibr1-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00631.x"},{"key":"bibr2-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1111\/head.12201"},{"key":"bibr3-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1177\/2164956119858034"},{"key":"bibr4-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414535110"},{"key":"bibr5-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02155.x"},{"key":"bibr6-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000052998.58526.A9"},{"key":"bibr7-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg190"},{"key":"bibr8-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"bibr9-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0566-9"},{"key":"bibr10-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-004-0062-0"},{"key":"bibr11-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1111\/head.13501"},{"key":"bibr12-0333102420963844","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2019.03.009"},{"key":"bibr13-0333102420963844","unstructured":"National Board of Chiropractic Examiners Practice Analysis of Chiropractic 2020 National Board of Chiropractic Examiners, Greeley, CO (2020). 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