{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:13:55Z","timestamp":1791940435370,"version":"4.3.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness. Instituto de Salud Carlos III","award":["PI15\/01578"],"award-info":[{"award-number":["PI15\/01578"]}]},{"name":"Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS plus","award":["RD12\/0014\/0009"],"award-info":[{"award-number":["RD12\/0014\/0009"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recently, amylin and its receptors were found in different structures involved in migraine pathophysiology. Here, we evaluate interictal concentrations of amylin and calcitonin gene-related peptide in peripheral blood as biomarkers for chronic migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively recruited patients with episodic migraine, chronic migraine and healthy controls. Interictal amylin and calcitonin gene-related peptide levels were assessed in blood samples using enzyme linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We assessed plasma samples from 58 patients with episodic migraine (mean age 37.71\u2009\u00b1\u200910.47, 87.9% female), 191 with chronic migraine (mean age 46.03\u2009\u00b1\u200911.93, 95% female), and on 68 healthy controls (mean age 43.58\u2009\u00b1\u200911.08 years, 86% female). Body mass index was 25.94\u2009\u00b1\u20094.53\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      for migraine patients and 25.13\u2009\u00b1\u20094.92\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      for healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0683). Interictal plasma amylin levels were higher in chronic migraine patients (47.1 pg\/mL) than in the episodic migraine patients (28.84 pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and healthy controls (24.74 pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Plasma calcitonin gene-related peptide levels were increased (20.01 pg\/mL) in chronic migraine patients when compared to healthy controls (11.37 pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0016), but not to episodic migraine patients (18.89 pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.4369). Applying a cut-off concentration of 39.68 pg\/mL plasma amylin, the sensitivity to differentiate chronic migraine from healthy controls was 57.6% and the specificity was 88.2%. Variables such as age, analgesic overuse, depression, allodynia, use of preventive medication or a history of aura did not influence the plasma concentrations of amylin or calcitonin gene-related peptide.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Interictal plasma amylin levels are higher in patients with chronic migraine and may serve as a diagnostic biomarker for chronic migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102420977106","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T10:16:06Z","timestamp":1606990566000},"page":"604-612","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Interictal amylin levels in chronic migraine patients: A case-control study"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-0036","authenticated-orcid":false,"given":"Pablo","family":"Irimia","sequence":"first","affiliation":[{"name":"Department of Neurology, Cl\u00ednica Universidad de Navarra, Pamplona, Spain"},{"name":"Navarra\u2019s Health Research Institute (IDISNA), Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Mart\u00ednez-Valbuena","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cl\u00ednica Universidad de Navarra, Pamplona, Spain"},{"name":"Navarra\u2019s Health Research Institute (IDISNA), Pamplona, Spain"},{"name":"Regenerative Therapy Laboratory, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-3920","authenticated-orcid":false,"given":"Ane","family":"M\u00ednguez-Olaondo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cl\u00ednica Universidad de Navarra, Pamplona, Spain"},{"name":"Department of Neurology, Hospital Universitario Donostia, San Sebasti\u00e1n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Dom\u00ednguez-Vivero","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Cl\u00ednico Universitario, Universidade de Santiago de Compostela, Spain"},{"name":"Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Antonio","family":"S\u00e1nchez-Arias","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cl\u00ednica Universidad de Navarra, Pamplona, Spain"},{"name":"Navarra\u2019s Health Research Institute (IDISNA), Pamplona, Spain"},{"name":"Regenerative Therapy Laboratory, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Mart\u00ednez-Vila","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cl\u00ednica Universidad de Navarra, Pamplona, Spain"},{"name":"Navarra\u2019s Health Research Institute (IDISNA), Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Rosario","family":"Luquin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cl\u00ednica Universidad de Navarra, Pamplona, Spain"},{"name":"Navarra\u2019s Health Research Institute (IDISNA), Pamplona, Spain"},{"name":"Regenerative Therapy Laboratory, Neurosciences Division, Center for Applied Medical Research (CIMA), University of 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