{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:33:48Z","timestamp":1777491228903,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We propose a new outcome measure to assess the efficacy of migraine treatments translating the approach of the Global Burden of Disease studies from a societal to an individual level: Instead of calculating \u201cyears lived with disability\u201d, we suggest estimating \u201ctime lost due to an attack\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Time lost due to an attack is calculated by multiplying the duration and the degree of impaired functioning during an attack.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Time lost due to an attack, different from other outcome measures, does not just focus on the short-term analgesic effects of treatments, but rather on the improvement of all migraine symptoms and restoration of functioning, also considering therapy-related impairment. Importantly, time lost due to an attack measures the entire time patients are not functioning normally, from onset to complete resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Time lost due to an attack represents a new paradigm to assess migraine burden in single patients for a patient-centered evaluation of both acute and prophylactic treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024211006048","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T01:22:55Z","timestamp":1618881775000},"page":"1027-1032","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Time lost due to an attack \u2013 a novel patient-reported outcome measure for acute migraine treatments"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-6790","authenticated-orcid":false,"given":"Heiko","family":"Pohl","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6316-430X","authenticated-orcid":false,"given":"Silvia","family":"Benemei","sequence":"additional","affiliation":[{"name":"Careggi University Hospital, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-1064","authenticated-orcid":false,"given":"David","family":"Garcia-Azorin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Dixon","sequence":"additional","affiliation":[{"name":"MEDIAN Kinzigtal-Klinik, Bad Soden-Salm\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Huzzey","sequence":"additional","affiliation":[{"name":"Watford Osteopaths, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel D","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"bibr1-03331024211006048","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419828967"},{"key":"bibr2-03331024211006048","doi-asserted-by":"publisher","DOI":"10.1159\/000116757"},{"key":"bibr3-03331024211006048","volume-title":"Center for Drug 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